Central Nervous System

ABSTRACTS

*Duke authors bolded

BMX-HGG: Phase II trial of newly diagnosed high-grade glioma treated with concurrent radiation therapy, temozolomide, and BMX-001.
SESSION
Central Nervous System Tumors
AUTHOR(S)
Katherine B. Peters, Adam Louis Cohen, Nicholas A. Butowski, John L. Villano, Pierre Giglio, Tresa McGranahan, Chi Zhang, Timothy Francis Cloughesy, James Emmett Herndon, Patrick Healy, David MacLeod, Sara Penchev, David Silberstein, Ines Batinic-Haberle, Ivan Spasojevic, Shayne Gad, David Radoff, Daniel Barboriak, James Crapo
ABSTRACT / POSTER TPS2577 ● 68

Phase I trial of D2C7 immunotoxin (D2C7-IT) administered intratumorally via convection-enhanced delivery (CED) for recurrent malignant glioma (MG).
SESSION
Central Nervous System Tumors
AUTHOR(S)
Annick Desjardins, Dina Randazzo, Vidyalakshmi Chandramohan, Katherine B. Peters, Margaret O Johnson, Stevie Threatt, Chevelle A Bullock, James Emmett Herndon, Patrick Healy, Eric S Lipp, John H. Sampson, Allan H. Friedman, Henry S. Friedman, David M. Ashley, Darell D. Bigner
ABSTRACT / POSTER 2566 ● 57

Alliance A071701: Genomically guided treatment trial in brain metastases.
SESSION
Central Nervous System Tumors
AUTHOR(S)
Priscilla Kaliopi Brastianos, Erin Twohy, Carey K. Anders, A. John Iafrate, Peter A. Kaufman, Justine Vanessa Cohen, Rebecca Suk Heist, Elizabeth Robins Gerstner, Timothy J. Kaufmann, Susan Geyer, Laura Hoffman, Priya Kumthekar, Frederick G. Barker, Scott L. Carter, Paul D. Brown, Evanthia Galanis
ABSTRACT / POSTER TPS2573 ● 64

Vorasidenib (VOR; AG-881), an inhibitor of mutant IDH1 and IDH2, in patients (pts) with recurrent/progressive glioma: Updated results from the phase I non-enhancing glioma population.
SESSION
Central Nervous System Tumors
AUTHOR(S)
Ingo K. Mellinghoff, Katherine B. Peters, Timothy Francis Cloughesy, Howard A. Burris III, Elizabeth Anne Maher, Filip Janku, Gregory Michael Cote, Macarena Ines De La Fuente, Jennifer Leigh Clarke, Kha Le, Li Liu, Man Yuen, Marissa Arnofsky, Islam Hassan, Lori Steelman, Shuchi Sumant Pandya, Patrick Y. Wen
ABSTRACT 2504

INDIGO: A global, randomized, double-blind, phase III study of vorasidenib (VOR; AG-881) vs placebo in patients (pts) with residual or recurrent grade II glioma with an isocitrate dehydrogenase 1/2 (IDH1/2) mutation.
SESSION
Central Nervous System Tumors
AUTHOR(S)
Ingo K. Mellinghoff, Martin J. Van Den Bent, Jennifer Leigh Clarke, Elizabeth Anne Maher, Katherine B. Peters, Mehdi Touat, John Frederick De Groot, Macarena Ines De La Fuente, Isabel Arrillaga-Romany, Wolfgang Wick, Benjamin M. Ellingson, Steven Schoenfeld, Feng Tai, Kha Le, Min Lu, Lori Steelman, Islam Hassan, Shuchi Sumant Pandya, Patrick Y. Wen, Timothy Francis Cloughesy
ABSTRACT / POSTER TPS2574 ● 65

Randomized phase II study of rituximab, methotrexate (MTX), procarbazine, vincristine, and cytarabine (R-MPV-A) with and without low-dose whole-brain radiotherapy (LD-WBRT) for newly diagnosed primary CNS lymphoma (PCNSL).
SESSION
Central Nervous System Tumors
AUTHOR(S)
Antonio Marcilio Padula Omuro, Lisa Marie DeAngelis, Theodore Karrison, Joe A Bovi, Marc Rosenblum, Benjamin W. Corn, Denise Correa, Jeffrey Scott Wefel, Sanjay Aneja, Christian Grommes, Lauren Schaff, Steven E. Waggoner, Enrico C. Lallana, Maria Werner-Wasik, Fabio Iwamoto, Timothy J. Robinson, Eric Donnelly, Timothy Struve, Minhee Won, Minesh P. Mehta
ABSTRACT 2501

MDNA55 survival in recurrent glioblastoma (rGBM) patients expressing the interleukin-4 receptor (IL4R) as compared to a matched synthetic control.
SESSION
Central Nervous System Tumors
AUTHOR(S)
John H. Sampson, Achal Achrol, Manish K. Aghi, Krystof Bankiewicz, Martin Bexon, Steven Brem, Andrew Jacob Brenner, Chandtip Chandhasin, Sajeel A. Chowdhary, Melissa Coello, Sunit Das, Seunggu Jude Han, Santosh Kesari, Fahar Merchant, Nina Merchant, Dina Randazzo, Michael A. Vogelbaum, Frank Vrionis, Miroslaw Zabek, Nicholas A. Butowski
ABSTRACT / POSTER 2513 ● 4

Molecular features of gliomas with high tumor mutational burden.
SESSION
Central Nervous System Tumors
AUTHOR(S)
Joanne Xiu, Kyle M Walsh, Manjari Pandey, Emil Lou, Ekokobe Fonkem, Herbert B. Newton, Erin M. Dunbar, Macarena Ines De La Fuente, Michael J. Glantz, Sandeep Mittal, David M. Ashley, Wolfgang Michael Korn, Ashley Love Sumrall
ABSTRACT / POSTER 2549 ● 40

Patterns of inpatient palliative care consultation for patients with brain and spine metastases.
SESSION
Publication Only: Symptoms and Survivorship
AUTHOR(S)
Elizabeth Howell, Meghan Price, Tara Dalton, Theresa Williamson, Arif Kamal, Rory Goodwin
ABSTRACT e24117

Brain metastasis from esophageal squamous cell carcinoma: Clinical characteristics and prognosis.
SESSION
Publication Only: Gastrointestinal Cancer—Gastroesophageal, Pancreatic, and Hepatobiliary
AUTHOR(S)
Linlin Xiao, Yvonne Marie Mowery, Jun Wang, Min Zhao, Shaowu Jing, Guangbin Gao
ABSTRACT e16525

Real-world burden of chemotherapy-induced myelosuppression: Results of a U.S. online survey of patients with cancer.
SESSION
Publication Only: Health Services Research and Quality Improvement
AUTHOR(S)
Robert S. Epstein, Matti S. Aapro, Upal K. Basu Roy, Tehseen Salimi, JoAnn Krenitsky, Megan L. Leone-Perkins, Jeffrey Crawford
ABSTRACT e19299