Heme Malignancies

ABSTRACTS

*Duke authors bolded

A phase I/II study of IMGN632, a novel CD123-targeting antibody-drug conjugate, in patients with relapsed/refractory acute myeloid leukemia, blastic plasmacytoid dendritic cell neoplasm, and other CD123-positive hematologic malignancies
SESSION
Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant
AUTHOR(S)
Naval Guastad Daver, Pau Montesinos, Daniel J. DeAngelo, Eunice S. Wang, Elisabetta Todisco, Corrado Tarella, Giovanni Martinelli, Harry Paul Erba, Eric Deconinck, Kendra L Sweet, Roland B. Walter, Moshe Yair Levy, Naveen Pemmaraju, Andrew A. Lane, David Rizzieri, Marina Konopleva, Callum Mortimer Sloss, Jiuzhou Wang, Kara E Malcolm, Patrick A Zweidler-McKay
ABSTRACT / POSTER TPS7563 ● 336

A phase Ib/II study of the CD123-targeting antibody-drug conjugate IMGN632 as monotherapy or in combination with venetoclax and/or azacitidine for patients with CD123-positive acute myeloid leukemia
SESSION
Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant
AUTHOR(S)
Naval Guastad Daver, Eunice S. Wang, Kendra L Sweet, Pau Montesinos, Harry Paul Erba, Daniel J. DeAngelo, Callum Mortimer Sloss, Jiuzhou Wang, Kara E Malcolm, Patrick A Zweidler-McKay
ABSTRACT / POSTER TPS7564 ● 337

A fork in the road: A mixed methods study exploring why older adults with acute myeloid leukemia choose different treatment paths
SESSION
Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant
AUTHOR(S)
Thomas William LeBlanc, Roland B. Walter, Loriana Hernandez, Lucy Morgan, Timothy Bell, Charlotte Panter, Francois Peloquin, Jasmine Healy, Adam Gater, Verna Welch, Karim Amer, Louise O'Hara, Ryan Hohman, Andrew Brown, Nigel Russell, Diana M. Merino, Neil Horikoshi, Dawn Maze
ABSTRACT / POSTER 7520 ● 293

Mantle cell lymphoma: initial report from the North American Mantle Cell Lymphoma Consortium
SESSION
Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
AUTHOR(S)
Kai Fu, Guohua Yu, Chengfeng Bi, Hongxia Cheng, Lynette Smith, Ji Yuan, Hina Naushad, Brian K. Link, Craig R. Nichols, Paul M. Barr, Brad S. Kahl, Douglas Stewart, Stefan K Barta, Anne Beaven, Ranjana H. Advani, Peter Martin, Timothy Greiner, Dennis Weisenburger, James O. Armitage, Julie Vose
ABSTRACT / POSTER 8035 ● 368

Relevance of bone marrow biopsies for response assessment in NCTN follicular lymphoma clinical trials
SESSION
Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
AUTHOR(S)
Sarah C. Rutherford, Jun Yin, Levi Pederson, Betsy LaPlant, Mazyar Shadman, Hongli Li, Michael Leo LeBlanc, Kristie A. Blum, Travis Dockter, Peter Martin, Sin-Ho Jung, Barbara W. Grant, Cara Ann Rosenbaum, Chaitra Shankar Ujjani, Paul M. Barr, Joseph M. Unger, Bruce D. Cheson, Nancy L. Bartlett, Jonathan W. Friedberg, John Paul Leonard
ABSTRACT / POSTER 8038 ● 371

Updated results from BELLINI, a phase III study of venetoclax or placebo in combination with bortezomib and dexamethasone in relapsed/refractory multiple myeloma
SESSION
Hematologic Malignancies—Plasma Cell Dyscrasia
AUTHOR(S)
Shaji Kumar, Simon J. Harrison, Michele Cavo, Javier de La Rubia, Rakesh Popat, Cristina Gasparetto, Vania Hungria, Hans Salwender, Kenshi Suzuki, Inho Kim, Francesca Gay, Gabor Mikala, Elizabeth Punnoose, Wan-Jen Hong, Anjla Sood, Muhammad Jalaluddin, Jeremy A. Ross, James M Pauff, Paulo Cesar Maciag, Philippe Moreau
ABSTRACT / POSTER 8509 ● 409

Impact of lenalidomide-bortezomib-dexamethasone (RVd) induction on patients with newly diagnosed multiple myeloma and renal impairment: Results from the Connect MM Registry
SESSION
Hematologic Malignancies—Plasma Cell Dyscrasia
AUTHOR(S)
Sikander Ailawadhi, Hans Chulhee Lee, Jim Omel, Kathleen Toomey, James W. Hardin, Cristina Gasparetto, Sundar Jagannath, Robert M. Rifkin, Brian G. Durie, Mohit Narang, Howard R. Terebelo, Lynne I. Wagner, Mazaher Dhalla, Mia He, Shankar Srinivasan, Prashant Ramesh Joshi, Suzanne Robinson, Rafat Abonour
ABSTRACT / POSTER 8518 ● 418

Molecular diagnostic testing patterns in patients (pts) with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) in the Connect MDS/AML Registry
SESSION
Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant
AUTHOR(S)
Tracy George, Jay L. Patel, Mehrdad Abedi, Christopher R. Cogle, Harry Paul Erba, Guillermo Garcia-Manero, David L. Grinblatt, Pavel Kiselev, Rami S. Komrokji, Chrystal Ursula Louis, Jaroslaw P. Maciejewski, Melissa Nifenecker, Daniel Aaron Pollyea, Gail J. Roboz, Michael R. Savona, Bart L. Scott, Mikkael A. Sekeres, David P. Steensma, Michael A. Thompson, Kathryn Foucar
ABSTRACT / POSTER 7553 ● 326

Selinexor, daratumumab, and dexamethasone in patients with relapsed/refractory multiple myeloma (MM)  SESSION
Hematologic Malignancies—Plasma Cell Dyscrasia
AUTHOR(S)
Cristina Gasparetto, Suzanne Lentzsch, Gary J. Schiller, Natalie Scott Callander, Sascha Tuchman, Nizar J. Bahlis, Darrell White, Christine Chen, Muhamed Baljevic, Heather J Sutherland, Rami Kotb, Michael Sebag, Richard LeBlanc, Christopher P Venner, William Bensinger, Adriana C. Rossi, Heidi Sheehan, Melina Arazy, Kazuharu Kai, Brea Lipe
ABSTRACT / POSTER 8510 ● 410

Once weekly selinexor, carfilzomib, and dexamethasone (SKd) in patients with relapsed/refractory multiple myeloma (MM)
SESSION
Hematologic Malignancies—Plasma Cell Dyscrasia
AUTHOR(S)
Cristina Gasparetto, Brea Lipe, Sascha Tuchman, Natalie Scott Callander, Suzanne Lentzsch, Muhamed Baljevic, Adriana C. Rossi, Nizar J. Bahlis, Darell White, Christine Chen, Heather J Sutherland, Rami Kotb, Richard LeBlanc, Michael Sebag, Christopher P Venner, William Bensinger, Heidi Sheehan, Yawen Ju, Kazuharu Kai, Gary J. Schiller
ABSTRACT / POSTER 8530 ● 430

Interim analysis (IA) of OPTIC: A dose-ranging study of three ponatinib (PON) starting doses
SESSION
Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant
AUTHOR(S)
Jorge E. Cortes, Elza Lomaia, Anna Turkina, Beatriz Moiraghi, Maria Undurraga Sutton, Carolina Pavlovsky, Christine Rojas, Charles Chuah, Christopher Kevin Arthur, Jane Apperley, Dong-Wook Kim, Andreas Hochhaus, Philippe H. Rousselot, Gianantonio Rosti, Michael J. Mauro, Jeffrey Howard Lipton, Daniel Naranjo, Guohui Liu, Shouryadeep Srivastava, Michael W.N. Deininger
ABSTRACT 7502

Effect of adding ublituximab to ibrutinib on PFS, ORR, and MRD negativity in previously treated high-risk chronic lymphocytic leukemia: Final results of the GENUINE phase III study
SESSION
Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
AUTHOR(S)
Jeff P. Sharman, Danielle M. Brander, Anthony R. Mato, Nilanjan Ghosh, Stephen J. Schuster, Suman Kambhampati, John M. Burke, Frederick Lansigan, Marshall T. Schreeder, Scott D Lunin, Alexander Zweibach, Mikhail Shtivelband, Patrick M. Travis, Jason Claud Chandler, Kathryn S. Kolibaba, Peter Sportelli, Hari P. Miskin, Michael S. Weiss, Ian Flinn
ABSTRACT / POSTER 8022 ● 355

Association of CEP72 rs924607 with vincristine-induced peripheral neuropathy (PN) in patients with diffuse large B-cell lymphoma on CALGB 50303 (Alliance)
SESSION
Publication Only: Cancer Prevention, Risk Reduction, and Genetics
AUTHOR(S)
Daniel Louis Hertz, Nicholas Bradley Larson, Timothy Pierpont, Nancy L. Bartlett, Andrew David Zelenetz, Wyndham Hopkins Wilson, John Paul Leonard, Sin-Ho Jung, Shaun M. Riska, Kristy L. Richards
ABSTRACT e13535

Multisite randomized trial of integrated palliative and oncology care for patients with acute myeloid leukemia (AML)
SESSION
Symptoms and Survivorship
AUTHOR(S)
Areej El-Jawahri, Thomas William LeBlanc, Alison Kavanaugh, Jason Webb, Vicki A. Jackson, Toby Christopher Campbell, Nina O'Connor, Selina M. Luger, Ellin Gafford, Jillian Gustin, Bhavana Bhatnagar, Amir Tahmasb Fathi, Gabriela Hobbs, Julia Foster, Showly Nicholson, Debra M. Davis, Hilena Addis, Dagny Vaughn, Nora K. Horick, Jennifer Temel
ABSTRACT 12000

Impact of palliative care on end-of-life outcomes in hematologic malignancies
SESSION
Symptoms and Survivorship
AUTHOR(S)
Ari Pelcovits, Dominic Decker, Dana Guyer, Thomas William LeBlanc, Adam J. Olszewski, Pamela Egan
ABSTRACT / POSTER 12026 ● 314

Fatigue trajectories in long-term non-Hodgkin lymphoma survivors
SESSION
Publication Only: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
AUTHOR(S)
Matthew Roger LeBlanc, Sheryl Zimmerman, Mariam Kayle, Thomas William LeBlanc, Kathryn Elizabeth Hudson, Sophia Kustas Smith
ABSTRACT e20053

Toxicity burden in older patients with chronic lymphocytic leukemia (CLL) receiving bendamustine with rituximab (BR) or ibrutinib (IB) regimens: Alliance A041202
SESSION
Publication Only: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
AUTHOR(S)
Amy S. Ruppert, Sumithra J. Mandrekar, Allison M. Booth, Wei Ding, Nancy L. Bartlett, Danielle M. Brander, Steve E. Coutre, Jennifer R. Brown, Sreenivasa R. Nattam, Richard A. Larson, Harry Paul Erba, Mark Robert Litzow, Carolyn Owen, Charles S. Kuzma, Jeremy S. Abramson, Richard F. Little, Scott E. Smith, Richard M. Stone, John C. Byrd, Jennifer Ann Woyach
ABSTRACT e20004

Adult lymphoma-associated hemophagocytic lymphohistiocytosis: A clinical case series in a predominantly Hispanic cohort from the University of Miami/Jackson Memorial Hospital
SESSION
Publication Only: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia
AUTHOR(S)
Eduardo Edelman Saul, Amrita Desai, Jennifer Chapman, Lazaros J. Lekakis, Alexandra Stefanovic, Agustin Pimentel
ABSTRACT e20060

Prevalence, screening, treatment, and complications of osteoporosis and osteopenia in Medicare patients with chronic lymphocytic leukemia (CLL)
SESSION
Publication Only: Symptoms and Survivorship
AUTHOR(S)
Danielle M. Brander, Kevin C. Oeffinger, Melissa A. Greiner, Michaela Ann Dinan
ABSTRACT e24050

Real-world examination of remission patterns in patients (pts) with acute myeloid leukemia (AML)
SESSION
Publication Only: Health Services Research and Quality Improvement
AUTHOR(S)
Ashley Tabah, David Huggar, Brenna L. Brady, Krutika Jariwala-Parikh, Ronda Copher, Thomas William LeBlanc
ABSTRACT e19336