Tucatinib and Trastuzumab in Patients with HER2+ Metastatic Colorectal Cancer

What is the Purpose of this Study?

We are doing this study to look at the effects (good and/or bad) of taking study drugs Tucatinib and Trastuzumab has on you and your metastatic colorectal cancer.
What is the Condition Being Studied?
Metastatic Colorectal Cancer

Who Can Participate in this Study?

Adults who:

- Are diagnosed with metastatic colorectal cancer

- Have a positive test for HER2 overexpression or amplification

- Have not been treated with anti-HER2 therapy

Age Group
Participating Institutions

What is Involved?

If you choose to join this study, you will:

- Get the study drugs tucatinib and trastuzumab

-- Tucatinib is given by mouth twice a day and trastuzumab is given into your arm the first day of every 21 days in the clinic at Duke

-- This cycle will be repeated until your cancer gets worse or you have bad side effects or you choose to stop the study for any reason.

- Have tests, exams and procedures that are part of your standard of care and for study purposes. Clinic visits will usually last 4-5 hours

Study Details

Full Title
A Phase II, Open Label Study of Tucatinib Combined with Trastuzumab in Patients with HER2+ Metastatic Colorectal Cancer
Principal Investigator

Gastrointestinal Oncology DCI Clinical Research Team
Protocol Number

View on ClinicalTrials.gov