DF/HCC: 17-540 (Non-Small Cell Lung Cancer)

What is the Purpose of this Study?

If you choose to join this study, you will:
- Get study drugs Osimertinib and Selumetinib
-- You will take Osimertinib once a day every day and Selumetinib twice a day for 4 days
- Have routine eye exams
- Have blood samples and possibly a small piece of tissue removed from your lung to see what type of lung cancer cells you have
- Have other tests, exams, and procedures for study purposes and your standard of care
- Be in the study until your condition worsens or you have unbearable side effects
What is the Condition Being Studied?
Non-Small Cell Lung Cancer (NSCLC)

Who Can Participate in this Study?

Adults who have stage IV NSCLC with EGFR mutation.

Age Group
Participating Institutions

What is Involved?

We are doing this study to find out if a combination of the study drugs, Osimertinib and Selumetinib, are safe and will work in treating Non-Small Cell Lung Cancer (NSCLC) with a gene mutation.

Study Details

Full Title
A Phase 2 Study of osimertinib in combination with selumetinib in EGFR inhibitor naive advanced EGFR mutant lung cancer
Principal Investigator

Protocol Number

View on ClinicalTrials.gov