A Study of SEA-CD40 Given with Other Drugs in Cancers (Melanoma)
What is the Purpose of this Study?
- Get the study drug, SEA-CD40, through a vein in your arm (IV) every 6 weeks
- Get pembrolizumab through IV every 3 weeks
- Have physical exams
- Have blood draws
- Give urine samples
- Have regular MRI or CT scans during the study
- Possibly have a needle biopsy of your tumor
You will receive the study drugs for up to 2 years unless you have unwanted side effects or the study doctor finds that you are not getting better.
Who Can Participate in this Study?
Adults ages 18+ who:
- Are diagnosed with melanoma and have not gotten better after 3 rounds of therapy that include an anti-PD-(L)1 monoclonal antibody; OR
- Are diagnosed with metastatic uveal melanoma; OR
- Are diagnosed with metastatic melanoma and have never received an anti-PD-(L)1 monoclonal antibody
For more information about who can be in this study, please contact the study team at email@example.com
What is Involved?
We are doing this study to find out if an experimental drug called SEA-CD40 is a safe and effective treatment for melanoma when it's given in combination with pembrolizumab.