Gynecologic Cancer

Program Leadership

Andrew Berchuck, MD
Director
Angeles Secord, MD
Assoc. Director, Clinical Research
Donald McDonnell, PhD
Assoc. Director, Basic Research

Program Overview

Recent discoveries in genetics and genomics hold great promise for the development of target-defined prevention and chemotherapeutic strategies for gynecological cancers, including biomarkers development for targeted therapy and immunotherapy.

However, a coordinated, multi-disciplinary research effort is required to translate these new research discoveries into the next generation of therapeutic strategies.

To meet this challenge the Gynecologic Cancer Research Program aims to:

  • Define early events in gyncologic carcinogenesis
  • Translate these advances into targeted therapeutic approaches for the prevention and treatment of gynecologic cancer
  • Test these new therapies in investigator-initiated and multi-institutional clinical trials

Since its inception, the program has successfully fostered scientific interactions between members of the Duke Cancer Institute who have basic, translational, and clinical research interests in gynecologic cancer.

Within the domain of the program we developed five subprograms that draw from our translational research strength and ability to translate basic science discoveries to impact the early detection and treatment of gynecologic cancer:

  • Early detection strategies for gynecologic cancer
  • Methylation imprinting and epigenetic dysregulation
  • Basic gynecologic cancer biology and novel therapeutic targeting
  • Genomics
  • Disparities for African American women

The diversity of interest and experimental approaches used by the members of the Gynecologic Cancer Research Program represents an effective environment for fostering cross-fertilization of ideas aimed at understanding gynecologic cancer. In addition, the Program supports developmental projects, new faculty awards, and tissue procurement and banking.

Additional Contacts

Janice Tabor, Administrative Director
Phone: 919.684.8567

Toya Hobbs, Assistant Research Practice Manager
Phone: 919.684.2310

Clinical Trials

Make An Appointment

To make an appointment, please call 888.275.3853. For more information on gynecologic cancer care at Duke Health, visit:

To find a doctor, visit Find A Specialist.

Related News

Nationwide Ovarian Cancer Clinical Trial Shows Promise

Laura Elzie, 60, an IT architect with IBM, was first diagnosed with ovarian cancer three years ago. She turned to DCI gynecologic oncologist Angeles Secord, MD. Elzie underwent surgery followed by chemo-therapy. She later had the opportunity to participate in a clinical trial to potentially prolong remission. More