Rajan Gupta

Overview:

Abdominal Imaging; Multiparametric MR imaging of prostate cancer; MR imaging of the hepatobiliary system; Applications of dual energy CT in the abdomen and pelvis

Positions:

Associate Professor of Radiology

Radiology, Abdominal Imaging
School of Medicine

Associate Professor in Surgery

Surgery, Urology
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

M.D. 2003

Northwestern University

Grants:

Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) of Bone Marrow In Acute Myeloid Leukemia

Administered By
Radiology, Abdominal Imaging
Awarded By
Bayer Healthcare Pharmaceuticals Inc
Role
Principal Investigator
Start Date
End Date

Philips' IntelliSpace Precision Medicine (ISPM) platform and its prostate cancer application(s)

Administered By
Radiology, Abdominal Imaging
Awarded By
Philips Healthcare
Role
Principal Investigator
Start Date
End Date

Publications:

A randomized controlled trial comparing changes in fitness with or without supervised exercise in patients initiated on enzalutamide and androgen deprivation therapy for non-metastatic castration-sensitive prostate cancer (EXTEND).

BACKGROUND: Androgen deprivation therapy (ADT) and androgen receptor signaling inhibitors (ARSI) are associated with deleterious physical effects, which exercise may mitigate; however, exercise has never been studied in patients initiating treatment with ADT and an ARSI. Our objective was to determine whether supervised exercise prior to and during initial therapy could mitigate adverse effects of ADT plus enzalutamide. METHODS: We conducted a single center trial in patients with recurrent prostate cancer treated with ADT and enzalutamide. We randomized 26 patients to 16 weeks of supervised exercise (aerobic and resistance), starting 4 weeks before initiation of ADT and enzalutamide, or usual care. The primary endpoint was change in peak oxygen uptake (VO2peak) as a measure of cardiorespiratory fitness (CRF). Secondary endpoints were functional capacity, maximal strength, body composition, patient-reported outcomes, safety, and feasibility. Analysis of covariance was used to compare outcomes for groups at Week 17 adjusted for baseline values. RESULTS: The usual care group (N = 13) showed declines from baseline to week 17 in both absolute CRF (-0.31 L/min, -10.9%; p < 0.01) and relative CRF (-3.2 mL/kg/min, -8.9%; p = 0.04); worse fatigue (p = 0.01); and worse quality of life (p = 0.01). At week 17, the exercise group (N = 13) demonstrated improved absolute CRF (between-group change +0.20 L/min, p = 0.05), leg strength (+48.6 kg, p < 0.01) and functional capacity (+21.0 m, p = 0.01) at week 17. CONCLUSIONS: This is the first randomized controlled trial demonstrating a clinically significant decline in CRF in patients initiating ADT and enzalutamide. We show the effectiveness of short-term supervised exercise to mitigate declines in absolute CRF, and improve maximal leg strength and functional capacity. CLINICALTRIALS: GOV IDENTIFIER: NCT02256111.
Authors
Harrison, MR; Davis, PG; Khouri, MG; Bartlett, DB; Gupta, RT; Armstrong, AJ; McNamara, MA; Zhang, T; Anand, M; Onyenwoke, K; Edwardson, S; Craig, D; Michalski, M; Wu, Y; Oyekunle, T; Coyne, B; Coburn, A; Jones, LW; George, DJ
MLA Citation
URI
https://scholars.duke.edu/individual/pub1512698
PMID
35273377
Source
pubmed
Published In
Prostate Cancer Prostatic Dis
Volume
25
Published Date
Start Page
58
End Page
64
DOI
10.1038/s41391-022-00519-4

PD10-11 ANALYSIS OF THE PREDICTIVE UTILITY OF PROGNOSTIC GRADE GROUPS (PGG) FOR PREDICTING PERIOPERATIVE ONCOLOGIC OUTCOMES OF RADICAL PROSTATECTOMY IN THE SHARED EQUAL ACCESS REGIONAL CANCER HOSPITAL (SEARCH) DATABASE

Authors
Schulman, A; Howard, L; Tay, KJ; Gupta, R; Tsivian, E; Amling, C; Aronson, W; Cooperberg, M; Kane, C; Terris, M; Freedland, S; Polascik, T
MLA Citation
Schulman, Ariel, et al. “PD10-11 ANALYSIS OF THE PREDICTIVE UTILITY OF PROGNOSTIC GRADE GROUPS (PGG) FOR PREDICTING PERIOPERATIVE ONCOLOGIC OUTCOMES OF RADICAL PROSTATECTOMY IN THE SHARED EQUAL ACCESS REGIONAL CANCER HOSPITAL (SEARCH) DATABASE.” Journal of Urology, vol. 197, no. 4S, Ovid Technologies (Wolters Kluwer Health), 2017. Crossref, doi:10.1016/j.juro.2017.02.574.
URI
https://scholars.duke.edu/individual/pub1520073
Source
crossref
Published In
The Journal of Urology
Volume
197
Published Date
DOI
10.1016/j.juro.2017.02.574

PD03-10 VALIDATION OF THE 2015 PROSTATE CANCER PROGNOSTIC GRADE GROUPS FOR PREDICTING LONG-TERM ONCOLOGIC OUTCOMES IN A SHARED EQUAL ACCESS HEALTH SYSTEM.

Authors
Schulman, A; Howard, L; Tay, KJ; Gupta, R; Tsivian, E; Amling, C; Aronson, W; Cooperberg, M; Kane, C; Terris, M; Freedland, S; Polascik, T
MLA Citation
Schulman, Ariel, et al. “PD03-10 VALIDATION OF THE 2015 PROSTATE CANCER PROGNOSTIC GRADE GROUPS FOR PREDICTING LONG-TERM ONCOLOGIC OUTCOMES IN A SHARED EQUAL ACCESS HEALTH SYSTEM.Journal of Urology, vol. 197, no. 4S, Ovid Technologies (Wolters Kluwer Health), 2017. Crossref, doi:10.1016/j.juro.2017.02.216.
URI
https://scholars.duke.edu/individual/pub1520074
Source
crossref
Published In
The Journal of Urology
Volume
197
Published Date
DOI
10.1016/j.juro.2017.02.216

Pericardial Adipose Tissue Volume and Left Ventricular Assist Device-Associated Outcomes.

BACKGROUND: Pericardial adipose tissue (PAT) is associated with adverse cardiovascular outcomes in those with and without established heart failure (HF). However, it is not known whether PAT is associated with adverse outcomes in patients with end-stage HF undergoing left ventricular assist device (LVAD) implantation. This study aimed to evaluate the associations between PAT and LVAD-associated outcomes. METHODS AND RESULTS: We retrospectively measured computed tomography-derived PAT volumes in 77 consecutive adults who had available chest CT imaging prior to HeartMate 3 LVAD surgery between October 2015 and March 2019 at Duke University Hospital. Study groups were divided into above-median (≥219 cm3) and below-median (<219 cm3) PAT volume. Those with above-median PAT had a higher proportion of atrial fibrillation, chronic kidney disease and ischemic cardiomyopathy. Groups with above-median vs below-median PAT had similar Kaplan-Meier incidence rates over 2 years for (1) composite all-cause mortality, redo-LVAD surgery and cardiac transplantation (35.9 vs 32.2%; log-rank P = 0.65) and (2) composite incident hospitalizations for HF, gastrointestinal bleeding, LVAD-related infection, and stroke (61.5 vs 60.5%; log-rank P = 0.67). CONCLUSIONS: In patients with end-stage HF undergoing LVAD therapy, PAT is not associated with worse 2-year LVAD-related outcomes. The significance of regional adiposity vs obesity in LVAD patients warrants further investigation.
Authors
Rao, VN; Obeid, MJ; Rigiroli, F; Russell, SD; Patel, CB; Molinger, J; Gupta, RT; Agarwal, R; Fudim, M
MLA Citation
Rao, Vishal N., et al. “Pericardial Adipose Tissue Volume and Left Ventricular Assist Device-Associated Outcomes.J Card Fail, vol. 28, no. 1, Jan. 2022, pp. 149–53. Pubmed, doi:10.1016/j.cardfail.2021.06.021.
URI
https://scholars.duke.edu/individual/pub1488518
PMID
34274515
Source
pubmed
Published In
Journal of Cardiac Failure
Volume
28
Published Date
Start Page
149
End Page
153
DOI
10.1016/j.cardfail.2021.06.021

MP01-07 THE ADDED UTILITY OF DIGITAL TOMOSYNTHESIS TO STANDARD ABDOMINAL RADIOGRAPHY FOR IDENTIFICATION OF URINARY CALCULI

Authors
Wollin, D; Gupta, R; Young, B; Cone, E; Kaplan, A; Marin, D; Patel, B; Ferrandino, M; Preminger, G; Lipkin, M
MLA Citation
Wollin, Daniel, et al. “MP01-07 THE ADDED UTILITY OF DIGITAL TOMOSYNTHESIS TO STANDARD ABDOMINAL RADIOGRAPHY FOR IDENTIFICATION OF URINARY CALCULI.” Journal of Urology, vol. 197, no. 4S, Ovid Technologies (Wolters Kluwer Health), 2017. Crossref, doi:10.1016/j.juro.2017.02.082.
URI
https://scholars.duke.edu/individual/pub1520075
Source
crossref
Published In
The Journal of Urology
Volume
197
Published Date
DOI
10.1016/j.juro.2017.02.082