Xiaoyin Jiang

Overview:

I am a pathologist specializing in cytopathology and surgical pathology. I diagnose diseases through integrating clinical history and studying patient samples under the microscope. As a cytopathologist, I perform fine needle aspiration biopsies in our clinic. I serve as Chief of the Head and Neck Service, and Director of the Duke Pathology Communications Group.
My research interests focus on the pathology of the head and neck and endocrine systems, with particular interest in thyroid nodules and neoplasia, and ultrasound-guided FNA. I work with a multidisciplinary team to improve our understanding of disease. I also focus on novel applications of social media for physicians and medical education.



Positions:

Associate Professor of Pathology

Pathology
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

M.D. 2009

Duke University School of Medicine

Resident, Pathology

Duke University School of Medicine

Fellow, Cytopathology

Duke University School of Medicine

Grants:

Rapid 3D whole-slide microscope digitization for thick cytopathology slides

Administered By
Pathology
Awarded By
Ramona Optics, Inc.
Role
Principal Investigator
Start Date
End Date

Publications:

Innovations: Innovating together while social distancing.

Authors
Jiang, XS; Madrigal, E
MLA Citation
Jiang, Xiaoyin Sara, and Emilio Madrigal. “Innovations: Innovating together while social distancing.Cancer Cytopathol, vol. 129, no. 2, Feb. 2021, pp. 99–101. Pubmed, doi:10.1002/cncy.22325.
URI
https://scholars.duke.edu/individual/pub1477875
PMID
33058521
Source
pubmed
Published In
Cancer Cytopathol
Volume
129
Published Date
Start Page
99
End Page
101
DOI
10.1002/cncy.22325

Global impact of the COVID-19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries.

BACKGROUND: To the authors' knowledge, the impact of the coronavirus disease 2019 (COVID-19) pandemic on cytopathology practices worldwide has not been investigated formally. In the current study, data from 41 respondents from 23 countries were reported. METHODS: Data regarding the activity of each cytopathology laboratory during 4 weeks of COVID-19 lockdown were collected and compared with those obtained during the corresponding period in 2019. The overall number and percentage of exfoliative and fine-needle aspiration cytology samples from each anatomic site were recorded. Differences in the malignancy and suspicious rates between the 2 periods were analyzed using a meta-analytical approach. RESULTS: Overall, the sample volume was lower compared with 2019 (104,319 samples vs 190,225 samples), with an average volume reduction of 45.3% (range, 0.1%-98.0%). The percentage of samples from the cervicovaginal tract, thyroid, and anorectal region was significantly reduced (P < .05). Conversely, the percentage of samples from the urinary tract, serous cavities, breast, lymph nodes, respiratory tract, salivary glands, central nervous system, gastrointestinal tract, pancreas, liver, and biliary tract increased (P < .05). An overall increase of 5.56% (95% CI, 3.77%-7.35%) in the malignancy rate in nongynecological samples during the COVID-19 pandemic was observed. When the suspicious category was included, the overall increase was 6.95% (95% CI, 4.63%-9.27%). CONCLUSIONS: The COVID-19 pandemic resulted in a drastic reduction in the total number of cytology specimens regardless of anatomic site or specimen type. The rate of malignancy increased, reflecting the prioritization of patients with cancer who were considered to be at high risk. Prospective monitoring of the effect of delays in access to health services during the lockdown period is warranted.
Authors
Vigliar, E; Cepurnaite, R; Alcaraz-Mateos, E; Ali, SZ; Baloch, ZW; Bellevicine, C; Bongiovanni, M; Botsun, P; Bruzzese, D; Bubendorf, L; Büttner, R; Canberk, S; Capitanio, A; Casadio, C; Cazacu, E; Cochand-Priollet, B; D'Amuri, A; Eloy, C; Engels, M; Fadda, G; Fontanini, G; Fulciniti, F; Hofman, P; Iaccarino, A; Ieni, A; Jiang, XS; Kakudo, K; Kern, I; Kholova, I; Liu, C; Lobo, A; Lozano, MD; Malapelle, U; Maleki, Z; Michelow, P; Musayev, J; Özgün, G; Oznur, M; Peiró Marqués, FM; Pisapia, P; Poller, D; Pyzlak, M; Robinson, B; Rossi, ED; Roy-Chowdhuri, S; Saieg, M; Savic Prince, S; Schmitt, FC; Javier Seguí Iváñez, F; Štoos-Veić, T; Sulaieva, O; Sweeney, BJ; Tuccari, G; van Velthuysen, M-L; VanderLaan, PA; Vielh, P; Viola, P; Voorham, R; Weynand, B; Zeppa, P; Faquin, WC; Pitman, MB; Troncone, G
MLA Citation
Vigliar, Elena, et al. “Global impact of the COVID-19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries.Cancer Cytopathol, vol. 128, no. 12, Dec. 2020, pp. 885–94. Pubmed, doi:10.1002/cncy.22373.
URI
https://scholars.duke.edu/individual/pub1463509
PMID
33108683
Source
pubmed
Published In
Cancer Cytopathol
Volume
128
Published Date
Start Page
885
End Page
894
DOI
10.1002/cncy.22373

#EBUSTwitter: Novel Use of Social Media for Conception, Coordination, and Completion of an International, Multicenter Pathology Study.

CONTEXT.—: Social media sites are increasingly used for education, networking, and rapid dissemination of medical information, but their utility for facilitating research has remained largely untapped. OBJECTIVE.—: To describe in detail our experience using a social media platform (Twitter) for the successful initiation, coordination, and completion of an international, multi-institution pathology research study. DESIGN.—: Following a tweet describing a hitherto-unreported biopsy-related histologic finding in a mediastinal lymph node following endobronchial ultrasound-guided transbronchial needle aspiration, a tweet was posted to invite pathologists to participate in a validation study. Twitter's direct messaging feature was used to create a group to facilitate communication among participating pathologists. Contributing pathologists reviewed consecutive cases of mediastinal lymph node resection following endobronchial ultrasound-guided transbronchial needle aspiration and examined them specifically for biopsy site changes. Data spreadsheets containing deidentified data and digital photomicrographs of suspected biopsy site changes were submitted via an online file hosting service for central review by 5 pathologists from different institutions. RESULTS.—: A total of 24 pathologists from 14 institutions in 5 countries participated in the study within 143 days of study conception, and a total of 297 cases were collected and analyzed. The time interval between study conception and acceptance of the manuscript for publication was 346 days. CONCLUSIONS.—: To our knowledge, this is the first time that a social media platform has been used to generate a research idea based on a tweet, recruit coinvestigators publicly, communicate with collaborating pathologists, and successfully complete a pathology study.
Authors
Lepe, M; Oltulu, P; Canepa, M; Wu, RI; Deeken, A; Alex, D; Dinares, C; Doxtader, EE; Fitzhugh, VA; Gibier, J-B; Jain, D; Janaki, N; Jelinek, A; Labiano, T; L'Imperio, V; Michael, C; Mukhopadhyay, S; Pagni, F; Panizo, A; Pijuan, L; Quintana, LM; Roy-Chowdhuri, S; Sanchez-Font, A; Sansano, I; Sauter, J; Skipper, D; Spruill, LS; Torous, V; Gardner, JM; Jiang, XS
MLA Citation
Lepe, Marcos, et al. “#EBUSTwitter: Novel Use of Social Media for Conception, Coordination, and Completion of an International, Multicenter Pathology Study.Arch Pathol Lab Med, vol. 144, no. 7, July 2020, pp. 878–82. Pubmed, doi:10.5858/arpa.2019-0297-OA.
URI
https://scholars.duke.edu/individual/pub1424885
PMID
31846366
Source
pubmed
Published In
Arch Pathol Lab Med
Volume
144
Published Date
Start Page
878
End Page
882
DOI
10.5858/arpa.2019-0297-OA

Social media in academics and research: 21st-century tools to turbocharge education, collaboration, and dissemination of research findings.

The near-ubiquitous use of smartphones and the rapid emergence of free, widely used, social media platforms have combined to turbocharge the dissemination of information at a scale and speed that would have been unimaginable just a few years ago. Increasingly, internet-savvy pathologists of all ages from every corner of the world are flipping the paradigm of traditional academia by posting educational content online free of charge, unencumbered by the limitations of traditional print media and educational conferences. These platforms are being used in innovative ways, not just to disseminate research findings, but also to create new knowledge through using them to empower research collaborations. In this review, we outline ways in which social media platforms, such as Twitter, Facebook, and YouTube, are being used by pathologists to enhance academic work and facilitate the dissemination of research. We outline key differences between the various platforms with respect to pathology academics and research, and describe key areas in which these platforms have already made an impact. These include rapid dissemination of research findings to a worldwide audience, live transnational discussion of journal articles and conference proceedings, intercontinental networking between pathologists for academic purposes, free education on a global scale at minimal or no cost, and research collaborations initiated on and facilitated by social media platforms. Finally, we provide practical tips for pathologists who wish to adopt these novel 21st-century technologies to enhance their academic endeavours.
Authors
Deeken, AH; Mukhopadhyay, S; Jiang, XS
MLA Citation
Deeken, Amy H., et al. “Social media in academics and research: 21st-century tools to turbocharge education, collaboration, and dissemination of research findings.Histopathology, vol. 77, no. 5, Nov. 2020, pp. 688–99. Epmc, doi:10.1111/his.14196.
URI
https://scholars.duke.edu/individual/pub1448867
PMID
32592211
Source
epmc
Published In
Histopathology
Volume
77
Published Date
Start Page
688
End Page
699
DOI
10.1111/his.14196

High-risk and intermediate-high-risk results from the ThyroSeq v2 and v3 thyroid genomic classifier are associated with neoplasia: Independent performance assessment at an academic institution.

BACKGROUND: The ThyroSeq panel tests for genetic alterations to risk-stratify cytologically indeterminate nodules. The authors assessed the test performance of the tests, including the latest version (v3), at an academic center. METHODS: Results from ThyroSeq testing (v2 and v3) were reviewed over 2 years, and patient demographics, cytology diagnoses, results of ThyroSeq testing, and histopathologic diagnoses on resection (if available) were collected. RESULTS: One hundred eighty-five nodules were tested from 178 patients, including 94 nodules tested with v2 and 91 nodules tested with v3. Overall, 28 of 185 nodules (15%) yielded a high-risk or intermediate-high-risk mutation (HRM). Of the patients with these nodules, 19 of 25 (76%) had neoplastic nodules, and 11 of 25 (44%) had a malignancy or a noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Only 16 of 147 nodules (11%) that were negative or had low-risk genetic alterations underwent resection, with 1 false-negative result (a papillary thyroid carcinoma tested with v2). No false-negative results were identified with v3. Two nodules had TP53 mutations identified, both of which were benign on resection. Nodules with HRM that were tested with v2 and v3 had a positive predictive value (PPV) for malignancy of 57% and 39%, respectively, and a PPV for neoplasm of 86% and 72%, respectively. The negative predictive values for v2 and v3 were 92% and 100%, respectively. CONCLUSIONS: The PPV of an HRM result on ThyroSeq v3 was low for malignancy or NIFTP, and the PPV for neoplasm was higher. RAS-type mutations were the most commonly identified in both benign and malignant nodules. Thyroseq v3 had a lower PPV for both malignancy/NIFTP and neoplasm than v2 but did not produce any false-negative results.
Authors
Jug, R; Foo, W-C; Jones, C; Ahmadi, S; Jiang, XS
MLA Citation
URI
https://scholars.duke.edu/individual/pub1438536
PMID
32339438
Source
pubmed
Published In
Cancer Cytopathol
Volume
128
Published Date
Start Page
563
End Page
569
DOI
10.1002/cncy.22283

Research Areas:

Cytopathology
Needle biopsy
Pathology
Pathology, Molecular
Pathology, Oral
Pathology, Surgical
Social Media
Thyroid Neoplasms
Thyroid Nodule