The PRiME Study (Brain Cancer)

What is the Purpose of this Study?

If you, or your child, choose to join this study, you or your child will:
- Have a blood test for a common virus called cytomegalovirus (CMV)
- Have standard radiation therapy with temozolomide (a chemotherapy) before study procedures
- Have blood drawn
- Get a Tetanus-diphtheria (Td) vaccine shot (given in the leg)
- Get the study vaccine (PEP-CMV) every 2 weeks for the first 3 vaccines and then once a month
What is the Condition Being Studied?
Brain Cancer (World Health Organization Grade III or IV glioma or medulloblastoma)

Who Can Participate in this Study?

Children and adults, 3-35 years old with:

- Grade III or IV glioma that has progressed or recurred

- Medulloblastoma that has progressed or recurred

Age Group
Participating Institutions

What is Involved?

We are doing this study to learn more about the study vaccine (PEP-CMV) and to understand if it helps the immune system fight brain cancer.

Study Details

Full Title
The PRiME Study: PEP-CMV in Recurrent MEdulloblastoma/malignant glioma
Principal Investigator

Protocol Number

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