ALVR106 in Treatment of High-Risk Patients with Respiratory Viral Infections After HSCT or SOT

What is the Purpose of this Study?

If you choose to join this study, you will:
- Be randomly assigned (like a coin flip) to get either the study drug or placebo (inactive substance)
- Have physical exams
- Have blood draws
- Have breathing tests
- Get a chest X-Ray or CT scan
- Have heart scans (ECG)

Depending on when you join the study, you will participate in Part A or Part B. In Part A, 4 different doses of the study drug will be tested. In Part B, only the most effective dose determined by Part A will be used.

Your participation in this study will last for about 1 year.
What is the Condition Being Studied?
Viral lung infections following bone marrow transplant

Who Can Participate in this Study?

Adults ages 18-75 who:

- Have a viral infection of the lungs (contact study team for eligible viral infections)

- Received a bone marrow transplant in the past 21 days

- Have not had a suspected COVID-19 infection in the last 28 days

For more information about who can join this study, please contact the study team at

Age Group
Participating Institutions

What is Involved?

We are doing this study to find out if an experimental drug called ALVR106 (study drug) is a safe and effective treatment for people who have viral lung infections after receiving a bone marrow transplant. We also want to determine what dose level of the drug works best.

Study Details

Full Title
Phase 1/2, Double-Blind, Placebo-Controlled, Dose Escalation and Expansion Study of ALVR106 in Addition to Standard of Care for the Treatment of High-Risk Patients with Respiratory Viral Infections After Hematopoietic Stem Cell Transplant
Principal Investigator

Hematological Malignancies, Cellular Therapy and ABMT
Protocol Number

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