SRS and Olaparaib followed by Durvalumab in Breast Cancer Brain Metastases
What is the Purpose of this Study?
- Take olaparib twice a day for two weeks before SRS
- Get an infusion (IV) of durvalumab every 21 days in combination with chemotherapy after you finish olaparib + SRS
- Have physical exams and blood draws
- Have imaging done (MRI and CT)
Your study doctor will determine what your chemotherapy regimen should be after you complete SRS.
Who Can Participate in this Study?
Adults ages 18+ who:
- Are diagnosed with breast cancer
- Have a newly diagnosed brain metastasis that can be treated with SRS
- Have not participated in a research study that uses durvalumab
- Have not received whole brain radiotherapy
- Are not pregnant
For more information about who can join this study, please contact the study team at 919-684-5301.
What is Involved?
We are doing this study to find out the highest dose of a drug called olaparib that is safe to give at
the same time as stereotactic radiosurgery (SRS). We also want to see if we can lessen the chance of having your cancer return by following the olaparib + SRS treatment with a combination of chemotherapy and a drug called durvalumab.