IDE196 in Metastatic Uveal or Non-Uveal Melanoma with GNAQ/11 Mutations or PRKC Fusions (IDEAYA)
What is the Purpose of this Study?
- Have a physical exam
- Have blood draws and give urine samples
- Have an eye exam
- Get a chest X-ray
- Have lung function tests
- If applicable, have a tumor biopsy to test for mutations in its genes
If you are eligible, you will continue on to the dosing period. During this period, you will:
- Take the study drug along with another drug called crizotinib by mouth every day for drug cycles that last 4 weeks each
- Have images (CT or MRI) taken of your tumors every 2 months for up to a year
The number of drug cycles you do will depend on how your body and cancer respond to the study drug and crizotinib.
Who Can Participate in this Study?
Adults ages 18+ who:
- Are diagnosed with uveal melanoma that has spread to other parts of their body (metastasis); OR
- Are diagnosed with another form of cancer that has a tumor mutation associated with the genes GNAQ, GNA11, or PRKC
For more information about who can be in this study, please contact the study team at email@example.com.
What is Involved?
We are doing this study to find out if an experimental drug called IDE196 (the study drug) is a safe and effective treatment for uveal melanoma (melanoma in the eye) that has spread to another part of the body or other types of cancer with a tumor mutation in genes called GNAQ, GNA11, or PRKC.