Gayathri Devi

Overview:

Dr. Devi’s research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer.

The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models.

Positions:

Associate Professor in Surgery

Surgery, Surgical Sciences
School of Medicine

Associate Professor in Pathology

Pathology
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

Ph.D. 1998

University of Nebraska College of Medicine

Grants:

Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression

Administered By
Surgery, Urology
Awarded By
National Institutes of Health
Role
Investigator
Start Date
End Date

GLI1 Inhibition to Enhance Chemo- and Targeted-Therapies in Inflammatory Breast Cancer

Administered By
Surgery, Surgical Sciences
Awarded By
North Carolina Central University
Role
Principal Investigator
Start Date
End Date

Role of XIAP in Therapeutic Resistance in Inflammatory Breast Cancer

Administered By
Surgery
Role
Principal Investigator
Start Date
End Date

Publications:

Advancement of multidisciplinary education and research in translational sciences: MERITS program development at Duke University.

Introduction: The Duke Multidisciplinary Education and Research in Translational Sciences Program provides educational resources for faculty and trainees in translational research. Methods: To aid in program development, we assessed perceptions of translational science through focus groups targeting different career stages. Results: In total, 3 essential themes emerged: collaboration, movement toward application, and public health impact. Facilitators and barriers varied among groups. Conclusion: Training programs must provide specific strategies for collaboration and selectively accelerating discoveries to therapies.
Authors
Freel, SA; Fish, LJ; Mirman, B; Sudan, R; Devi, GR
MLA Citation
Freel, Stephanie A., et al. “Advancement of multidisciplinary education and research in translational sciences: MERITS program development at Duke University..” J Clin Transl Sci, vol. 2, no. 1, Feb. 2018, pp. 57–62. Pubmed, doi:10.1017/cts.2018.17.
URI
https://scholars.duke.edu/individual/pub1417917
PMID
31660219
Source
pubmed
Published In
Journal of Clinical and Translational Science
Volume
2
Published Date
Start Page
57
End Page
62
DOI
10.1017/cts.2018.17

Islet Xenotransplantation: A Quest for Clinically Available Immunosuppression Regimens.

Authors
Fitch, ZW; Gao, Q; Davis, RP; Mulvihill, MS; Song, M; Leopardi, F; Ribeiro, M; How, T; Reimann, K; Devi, GR; Collins, BH; Kirk, AD
MLA Citation
Fitch, Z. W., et al. “Islet Xenotransplantation: A Quest for Clinically Available Immunosuppression Regimens..” American Journal of Transplantation, vol. 19, WILEY, 2019, pp. 473–74.
URI
https://scholars.duke.edu/individual/pub1402359
Source
wos
Published In
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume
19
Published Date
Start Page
473
End Page
474

CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation.

Authors
Song, M; Samy, K; Gao, Q; Davis, RP; Leopard, F; Fitch, Z; Bennett, C; Devi, GR; Collins, BH; Kirk, AD
MLA Citation
Song, M., et al. “CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation..” American Journal of Transplantation, vol. 19, WILEY, 2019, pp. 430–430.
URI
https://scholars.duke.edu/individual/pub1402758
Source
wos
Published In
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume
19
Published Date
Start Page
430
End Page
430

Analysis on drilling of woven glass fibre reinforced aluminium sandwich laminates

Authors
Ramya Devi, G; Palanikumar, K
MLA Citation
Ramya Devi, Gopalakrishnan, and Kayaroganam Palanikumar. “Analysis on drilling of woven glass fibre reinforced aluminium sandwich laminates.” Journal of Materials Research and Technology, vol. 8, no. 1, Elsevier BV, Jan. 2019, pp. 1024–35. Crossref, doi:10.1016/j.jmrt.2018.06.021.
URI
https://scholars.duke.edu/individual/pub1386275
Source
crossref
Published In
Journal of Materials Research and Technology
Volume
8
Published Date
Start Page
1024
End Page
1035
DOI
10.1016/j.jmrt.2018.06.021

Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium.

Inflammatory breast cancer (IBC) is an understudied and aggressive form of breast cancer with a poor prognosis, accounting for 2-6% of new breast cancer diagnoses but 10% of all breast cancer-related deaths in the United States. Currently there are no therapeutic regimens developed specifically for IBC, and it is critical to recognize that all aspects of treating IBC - including staging, diagnosis, and therapy - are vastly different than other breast cancers. In December 2014, under the umbrella of an interdisciplinary initiative supported by the Duke School of Medicine, researchers, clinicians, research administrators, and patient advocates formed the Duke Consortium for IBC to address the needs of patients in North Carolina (an ethnically and economically diverse state with 100 counties) and across the Southeastern United States. The primary goal of this group is to translate research into action and improve both awareness and patient care through collaborations with local, national and international IBC programs. The consortium held its inaugural meeting on Feb 28, 2018, which also marked Rare Disease Day and convened national research experts, clinicians, patients, advocates, government representatives, foundation leaders, staff, and trainees. The meeting focused on new developments and challenges in the clinical management of IBC, research challenges and opportunities, and an interactive session to garner input from patients, advocates, and community partners that would inform a strategic plan toward continuing improvements in IBC patient care, research, and education.
Authors
Devi, GR; Hough, H; Barrett, N; Cristofanilli, M; Overmoyer, B; Spector, N; Ueno, NT; Woodward, W; Kirkpatrick, J; Vincent, B; Williams, KP; Finley, C; Duff, B; Worthy, V; McCall, S; Hollister, BA; Palmer, G; Force, J; Westbrook, K; Fayanju, O; Suneja, G; Dent, SF; Hwang, ES; Patierno, SR; Marcom, PK
MLA Citation
Devi, Gayathri R., et al. “Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium..” J Cancer, vol. 10, no. 15, 2019, pp. 3344–51. Pubmed, doi:10.7150/jca.31176.
URI
https://scholars.duke.edu/individual/pub1395729
PMID
31293637
Source
pubmed
Published In
Journal of Cancer
Volume
10
Published Date
Start Page
3344
End Page
3351
DOI
10.7150/jca.31176