Gayathri Devi

Overview:

Dr. Devi’s research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer.

The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models.

Positions:

Associate Professor in Surgery

Surgery, Surgical Sciences
School of Medicine

Associate Professor in Pathology

Pathology
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

Ph.D. 1998

University of Nebraska, College of Medicine

Grants:

Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression

Awarded By
National Institutes of Health
Role
Investigator
Start Date
End Date

GLI1 Inhibition to Enhance Chemo- and Targeted-Therapies in Inflammatory Breast Cancer

Awarded By
North Carolina Central University
Role
Principal Investigator
Start Date
End Date

Publications:

Abstract P1-03-03: Multichannel serial imaging of transgenic, preclinical murine models provides the first quantitative analysis of the unusual growth kinetics and lymph-vascular invasion of patient-derived inflammatory breast cancer cells and tumor embol

Authors
Rickard, A; Patel, P; Sauer, SJ; Dewhirst, MW; Palmer, GM; Devi, GR
URI
https://scholars.duke.edu/individual/pub1443343
Source
crossref
Published In
Poster Session Abstracts
Published Date
DOI
10.1158/1538-7445.sabcs19-p1-03-03

Environmental Quality and Invasive Breast Cancer.

BACKGROUND: Breast cancer is a complex and multifactorial disease, and environmental factors have been suggested to increase its risk. However, prior research has largely focused on studying exposures to one factor/contaminant at a time, which does not reflect the real-world environment. METHODS: Herein, we investigate associations between breast cancer and the Environmental Quality Index (EQI), a comprehensive assessment of five domains of environmental quality (air, water, land, sociodemographic, and built) at the county level. Breast cancer diagnoses for North Carolina women were obtained from the North Carolina Central Cancer Registry (2009-2014) and the county of residence at the time of diagnosis was linked with the EQI. We evaluated the odds of localized, regional, or distant metastatic breast cancer in categories of environmental quality using women with carcinoma in situ as registry-based controls. RESULTS: Overall environmental quality was generally not associated with invasive breast cancer; however, all breast cancer types tended to be inversely associated with land quality, particularly in more rural communities [distant metastatic breast cancer was 5-8% more likely (OR 1.08; 95% CI: 1.02, 1.14, p=0.02) compared to carcinoma in situ]. CONCLUSIONS: Cumulatively, our results suggest that some broad measures of environmental quality are associated with invasive breast cancer but that associations vary by environmental domain, cancer stage, subtype, and urbanicity. IMPACT: Our findings suggest that components of land quality (e.g. pesticide applications and animal facilities) warrant additional investigation in relation to invasive breast cancer.
Authors
Gearhart-Serna, LM; Hoffman, K; Devi, GR
MLA Citation
Gearhart-Serna, Larisa M., et al. “Environmental Quality and Invasive Breast Cancer.Cancer Epidemiol Biomarkers Prev, Apr. 2020. Pubmed, doi:10.1158/1055-9965.EPI-19-1497.
URI
https://scholars.duke.edu/individual/pub1436877
PMID
32238404
Source
pubmed
Published In
Cancer Epidemiol Biomarkers Prev
Published Date
DOI
10.1158/1055-9965.EPI-19-1497

Advancement of multidisciplinary education and research in translational sciences: MERITS program development at Duke University.

Introduction: The Duke Multidisciplinary Education and Research in Translational Sciences Program provides educational resources for faculty and trainees in translational research. Methods: To aid in program development, we assessed perceptions of translational science through focus groups targeting different career stages. Results: In total, 3 essential themes emerged: collaboration, movement toward application, and public health impact. Facilitators and barriers varied among groups. Conclusion: Training programs must provide specific strategies for collaboration and selectively accelerating discoveries to therapies.
Authors
Freel, SA; Fish, LJ; Mirman, B; Sudan, R; Devi, GR
MLA Citation
Freel, Stephanie A., et al. “Advancement of multidisciplinary education and research in translational sciences: MERITS program development at Duke University.J Clin Transl Sci, vol. 2, no. 1, Feb. 2018, pp. 57–62. Pubmed, doi:10.1017/cts.2018.17.
URI
https://scholars.duke.edu/individual/pub1417917
PMID
31660219
Source
pubmed
Published In
Journal of Clinical and Translational Science
Volume
2
Published Date
Start Page
57
End Page
62
DOI
10.1017/cts.2018.17

Islet Xenotransplantation: A Quest for Clinically Available Immunosuppression Regimens.

Authors
Fitch, ZW; Gao, Q; Davis, RP; Mulvihill, MS; Song, M; Leopardi, F; Ribeiro, M; How, T; Reimann, K; Devi, GR; Collins, BH; Kirk, AD
MLA Citation
Fitch, Z. W., et al. “Islet Xenotransplantation: A Quest for Clinically Available Immunosuppression Regimens.American Journal of Transplantation, vol. 19, WILEY, 2019, pp. 473–74.
URI
https://scholars.duke.edu/individual/pub1402359
Source
wos
Published In
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume
19
Published Date
Start Page
473
End Page
474

CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation.

Authors
Song, M; Samy, K; Gao, Q; Davis, RP; Leopard, F; Fitch, Z; Bennett, C; Devi, GR; Collins, BH; Kirk, AD
MLA Citation
Song, M., et al. “CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation.American Journal of Transplantation, vol. 19, WILEY, 2019, pp. 430–430.
URI
https://scholars.duke.edu/individual/pub1402758
Source
wos
Published In
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume
19
Published Date
Start Page
430
End Page
430