Sarah Kelleher

Overview:

Sarah A. Kelleher, PhD is a Clinical Psychologist and Assistant Professor in the Department of Psychiatry and Behavioral Sciences at Duke University Medical Center. Dr. Kelleher is a member of the Duke Pain Prevention and Treatment Research Program and the Duke Cancer Control and Population Sciences Program. Dr. Kelleher completed her graduate training in clinical psychology at Virginia Tech and her clinical internship and postdoctoral fellowship at Duke University Medical Center. Her research focuses on developing, testing, and implementing behavioral symptom management interventions for patients with chronic disease.

Positions:

Assistant Professor in Psychiatry and Behavioral Sciences

Psychiatry & Behavioral Sciences, Behavioral Medicine
School of Medicine

Member of the

Duke Cancer Institute
School of Medicine

Education:

Ph.D. 2014

Virginia Polytech Institute and State University

Grants:

Pilot Testing a Virtual Reality Protocol for Improving Pain and Pain-Related Distress in Patients with Advanced Stage Colorectal Cancer

Administered By
Psychiatry & Behavioral Sciences, Behavioral Medicine
Awarded By
University of Colorado - Denver
Role
Principal Investigator
Start Date
End Date

Publications:

An mHealth Pain Coping Skills Training Intervention for Hematopoietic Stem Cell Transplantation Patients: Development and Pilot Randomized Controlled Trial (Preprint)

<sec> <title>BACKGROUND</title> <p>Pain is a challenge for patients following hematopoietic stem cell transplantation (HCT).</p> </sec> <sec> <title>OBJECTIVE</title> <p>This study aimed to develop and test the feasibility, acceptability, and initial efficacy of a Web-based mobile pain coping skills training (mPCST) protocol designed to address the needs of HCT patients.</p> </sec> <sec> <title>METHODS</title> <p>Participants had undergone HCT and reported pain following transplant (N=68). To guide intervention development, qualitative data were collected from focus group participants (n=25) and participants who completed user testing (n=7). After their input was integrated into the mPCST intervention, a pilot randomized controlled trial (RCT, n=36) was conducted to examine the feasibility, acceptability, and initial efficacy of the intervention. Measures of acceptability, pain severity, pain disability, pain self-efficacy, fatigue, and physical disability (self-report and 2-min walk test [2MWT]) were collected.</p> </sec> <sec> <title>RESULTS</title> <p>Participants in the focus groups and user testing provided qualitative data that were used to iteratively refine the mPCST protocol. Focus group qualitative data included participants’ experiences with pain following transplant, perspectives on ways to cope with pain, and suggestions for pain management for other HCT patients. User testing participants provided feedback on the HCT protocol and information on the use of videoconferencing. The final version of the mPCST intervention was designed to bridge the intensive outpatient (1 in-person session) and home settings (5 videoconferencing sessions). A key component of the intervention was a website that provided personalized messages based on daily assessments of pain and activity. The website also provided intervention materials (ie, electronic handouts, short videos, and audio files). The intervention content included pain coping advice from other transplant patients and instructions on how to apply pain coping skills while engaging in meaningful and leisure activities. In the RCT phase of this research, HCT patients (n=36) were randomized to receive the mPCST intervention or to proceed with the treatment as usual. Results revealed that the mPCST participants completed an average of 5 out of 6 sessions. The participants reported that the intervention was highly acceptable (mean 3/4), and they found the sessions to be helpful (mean 8/10) and easy to understand (mean 7/7). The mPCST participants demonstrated significant improvements in pre- to post-treatment pain, self-efficacy (P=.03, d=0.61), and on the 2MWT (P=.03, d=0.66), whereas the patients in the treatment-as-usual group did not report any such improvements. Significant changes in pain disability and fatigue were found in both groups (multiple P&lt;.02); the magnitudes of the effect sizes were larger for the mPCST group than for the control group (pain disability: d=0.79 vs 0.69; fatigue: d=0.94 vs 0.81). There were no significant changes in pain severity in either group.</p> </sec> <sec> <title>CONCLUSIONS</title> <p>Using focus groups and user testing, we developed an mPCST protocol that was feasible, acceptable, and beneficial for HCT patients with pain.</p> </sec> <sec> <title>CLINICALTRIAL</title> <p>ClinicalTrials.gov NCT01984671; https://clinicaltrials.gov/ct2/show/NCT01984671 (Archived by WebCite at http://www.webcitation.org/6xbpx3clZ)</p> </sec>
URI
https://scholars.duke.edu/individual/pub1466266
Source
crossref
DOI
10.2196/preprints.8565

Feasibility, engagement, and acceptability of a behavioral pain management intervention for colorectal cancer survivors with pain and psychological distress: data from a pilot randomized controlled trial.

PURPOSE: Colorectal cancer survivors report pain and psychological distress to be burdensome long-term cancer consequences. Quality cancer survivorship care includes interventions for managing these symptoms. Yet, no studies have tested the efficacy of an accessible behavioral intervention for colorectal cancer survivors with pain and comorbid psychological distress. This paper reports on the feasibility (i.e., accrual, attrition, and adherence to study procedures), engagement, acceptability, and descriptive outcomes of a telephone-based coping skills training (CST) intervention. METHODS: This randomized pilot trial assigned colorectal cancer patients (N=31) to 5 sessions of CST or standard care. CST sessions focused on cognitive-behavioral theory-based coping skills tailored to colorectal cancer symptoms of pain and psychological distress. Participants completed assessments of pain severity, self-efficacy for pain management, health-related quality of life, and psychological distress at baseline, post-treatment, and 3-month follow-up. RESULTS: Data indicated strong feasibility, evidenced by high completion rates for intervention sessions and assessments (93% completed all sessions; M=48.7 days; baseline=100%; post-treatment=97%; 3-month follow-up=94%). Participants demonstrated robust engagement with CST (M days per week with reported skills use=3.8) and reported high protocol satisfaction (M=3.6/4.0). Descriptive statistics showed self-efficacy for pain management and health-related quality of life improved for all participants. CONCLUSION: Findings suggest that a telephone-based CST intervention has strong feasibility, evidenced by accrual, low attrition, and adherence to intervention sessions and assessments. Likewise, participant engagement and acceptability with CST were high. These data provide a foundation for larger randomized efficacy trials of the telephone-based CST intervention.
Authors
URI
https://scholars.duke.edu/individual/pub1475456
PMID
33686520
Source
pubmed
Published In
Support Care Cancer
Published Date
DOI
10.1007/s00520-021-06126-8

Behavioral cancer pain intervention using videoconferencing and a mobile application for medically underserved patients: Rationale, design, and methods of a prospective multisite randomized controlled trial.

BACKGROUND: Women with breast cancer in medically underserved areas are particularly vulnerable to persistent pain and disability. Behavioral pain interventions reduce pain and improve outcomes. Cancer patients in medically underserved areas receive limited adjunctive cancer care, as many lack access to pain therapists trained in behavioral interventions, face travel barriers to regional medical centers, and may have low literacy and limited resources. mHealth technologies have the potential to decrease barriers but must be carefully adapted for, and efficacy-tested with, medically underserved patients. We developed an mHealth behavioral pain coping skills training intervention (mPCST-Community). We now utilize a multisite randomized controlled trial to: 1) test the extent mPCST-Community reduces breast cancer patients' pain severity (primary outcome), pain interference, fatigue, physical disability, and psychological distress; 2) examine potential mediators of intervention effects; and 3) evaluate the intervention's cost and cost-effectiveness. METHODS/DESIGN: Breast cancer patients (N = 180) will be randomized to mPCST-Community or an attention control. mPCST-Community's four-session protocol will be delivered via videoconferencing at an underserved community clinic by a remote pain therapist at a major medical center. Videoconference sessions will be supplemented with a mobile application. Participants will complete self-report measures at baseline, post-intervention, and 3- and 6-month follow-ups. CONCLUSIONS: mPCST-Community has the potential to reduce pain and disability, and decrease barriers for cancer patients in medically underserved areas. This is one of the first trials to test an mHealth behavioral cancer pain intervention developed specifically for medically underserved communities. If successful, it could lead to widespread implementation and decreased health disparities.
Authors
Kelleher, SA; Winger, JG; Fisher, HM; Miller, SN; Reed, SD; Thorn, BE; Spring, B; Samsa, GP; Majestic, CM; Shelby, RA; Sutton, LM; Keefe, FJ; Somers, TJ
MLA Citation
URI
https://scholars.duke.edu/individual/pub1472509
PMID
33497833
Source
pubmed
Published In
Contemp Clin Trials
Volume
102
Published Date
Start Page
106287
DOI
10.1016/j.cct.2021.106287

Understanding and enhancing pain coping in patients with arthritis pain

MLA Citation
Somers, T. J., et al. “Understanding and enhancing pain coping in patients with arthritis pain.” Psychosocial Factors in Arthritis: Perspectives on Adjustment and Management, 2016, pp. 35–52. Scopus, doi:10.1007/978-3-319-22858-7_3.
URI
https://scholars.duke.edu/individual/pub1454572
Source
scopus
Published Date
Start Page
35
End Page
52
DOI
10.1007/978-3-319-22858-7_3

Predictors of contralateral prophylactic mastectomy in genetically high risk newly diagnosed breast cancer patients

Authors
Tynan, M; Peshkin, BN; Isaacs, C; Willey, S; Valdimarsdottir, HB; Nusbaum, R; Hooker, G; O’Neill, SC; Jandorf, L; Kelly, SP; Heinzmann, J; Kelleher, S; Poggi, E; Schwartz, MD
MLA Citation
Tynan, Mara, et al. “Predictors of contralateral prophylactic mastectomy in genetically high risk newly diagnosed breast cancer patients.” Breast Cancer Research and Treatment, vol. 180, no. 1, Springer Science and Business Media LLC, Feb. 2020, pp. 177–85. Crossref, doi:10.1007/s10549-019-05515-2.
URI
https://scholars.duke.edu/individual/pub1436248
Source
crossref
Published In
Breast Cancer Research and Treatment
Volume
180
Published Date
Start Page
177
End Page
185
DOI
10.1007/s10549-019-05515-2