William Kraus

Overview:

My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes.  My research space has both a basic wet laboratory component and a human integrative physiology one.

One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).

A second focus of my research group is exploration of genetic determinates of disease risk in human subjects.  We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome.  We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.

A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.

Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes.  We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses.  We call this Lifestyle Medicopharmacogenetics.

KEY WORDS:

exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine

Positions:

Richard and Pat Johnson University Distinguished Professor

Medicine, Cardiology
School of Medicine

Professor of Medicine

Medicine, Cardiology
School of Medicine

Professor in the School of Nursing

School of Nursing
School of Nursing

Member of Duke Molecular Physiology Institute

Duke Molecular Physiology Institute
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

M.D. 1982

Duke University

Medical Resident, Medicine

Duke University

Fellow in Cardiology, Medicine

Duke University

Grants:

The Role of Ankyrin-B Mutations in Premature Senescence

Administered By
Medicine, Cardiology
Awarded By
National Institutes of Health
Role
Collaborator
Start Date
End Date

Epigenetic Mechanisms Promoting Longevity

Administered By
Duke Molecular Physiology Institute
Awarded By
National Institutes of Health
Role
Collaborator
Start Date
End Date

Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease

Administered By
Biomedical Engineering
Awarded By
National Institutes of Health
Role
Co Investigator
Start Date
End Date

Circulatory system and integrated muscle tissue for drug and tissue toxicity

Administered By
Biomedical Engineering
Awarded By
National Institutes of Health
Role
Co Investigator
Start Date
End Date

Effects of Chondroitin Sulfate and Chrondroitin Sulfate/Glucosamine on Muscle Immune Signaling and Function in TNF-alpha Stimulated Three Dimensional Muscle Cultures

Administered By
Biomedical Engineering
Awarded By
Bioiberica, S.A.
Role
Co Investigator
Start Date
End Date

Publications:

Plasma Metabolomic Profiles Differentiate Hemodynamic Subtypes of Pulmonary Hypertension

Authors
Luo, N; Craig, DM; Ilkayeva, O; Bain, J; Muehlbauer, M; Kraus, WE; Newgard, CB; Shah, SH; Rajagopal, S
MLA Citation
Luo, Nancy, et al. “Plasma Metabolomic Profiles Differentiate Hemodynamic Subtypes of Pulmonary Hypertension.” Circulation, vol. 132, LIPPINCOTT WILLIAMS & WILKINS, 2015.
URI
https://scholars.duke.edu/individual/pub1432871
Source
wos
Published In
Circulation
Volume
132
Published Date

Clinical Outcomes Associated With Titration of Medical Therapy for Heart Failure With Reduced Ejection Fraction: From the HF-ACTION Trial

Authors
Greene, SJ; O'Connor, CM; Sun, J-L; Fiuzat, M; Kraus, WE; Alhanti, B; Pina, IL; Whellan, D; Mentz, RJ
URI
https://scholars.duke.edu/individual/pub1443477
Source
wos-lite
Published In
Circulation
Volume
140
Published Date

Effects of exercise on plasma lipoproteins.

Authors
Sharma, AM
MLA Citation
Sharma, Arya M. “Effects of exercise on plasma lipoproteins.The New England Journal of Medicine, vol. 348, no. 15, Apr. 2003, pp. 1494–96. Epmc, doi:10.1056/nejm200304103481515.
URI
https://scholars.duke.edu/individual/pub1453371
PMID
12686709
Source
epmc
Published In
The New England Journal of Medicine
Volume
348
Published Date
Start Page
1494
End Page
1496
DOI
10.1056/nejm200304103481515

Exploring the Implications of Pain Symptoms in Patients With Heart Failure

Authors
Feng, KY; Oconnor, CM; Clare, R; Alhanti, B; Pina, IL; Kraus, WE; Whellan, DJ; Mentz, RJ
MLA Citation
Feng, Kent Y., et al. “Exploring the Implications of Pain Symptoms in Patients With Heart Failure.” Circulation, vol. 140, 2019.
URI
https://scholars.duke.edu/individual/pub1444950
Source
wos-lite
Published In
Circulation
Volume
140
Published Date

The Differential Effects Of Amount, Intensity, And Mode Of Exercise Training On A Novel Lipoprotein Multimarker Of Insulin Resistance

Authors
Ross, LM; Slentz, CA; Shalaurova, I; Connelly, MA; Otvos, JD; Bales, CW; Houmard, JA; Kraus, WE
MLA Citation
Ross, Leanna M., et al. “The Differential Effects Of Amount, Intensity, And Mode Of Exercise Training On A Novel Lipoprotein Multimarker Of Insulin Resistance.” Medicine & Science in Sports & Exercise, vol. 51, no. Supplement, Ovid Technologies (Wolters Kluwer Health), 2019, pp. 175–76. Crossref, doi:10.1249/01.mss.0000561029.25645.78.
URI
https://scholars.duke.edu/individual/pub1406973
Source
crossref
Published In
Medicine and Science in Sports and Exercise
Volume
51
Published Date
Start Page
175
End Page
176
DOI
10.1249/01.mss.0000561029.25645.78