Patricia Moorman
Overview:
Dr. Moorman's research focuses on the epidemiology of women's health issues. Her work includes research on ovarian cancer, breast cancer and hysterectomy. Areas of particular interest include disparities in cancer risk factors and outcomes and the effects of hysterectomy on ovarian function. As part of the Duke Evidence Synthesis group, she has also been involved in systematic reviews and meta-analyses related to ovarian cancer, breast cancer and infertility.
Positions:
Professor Emeritus in Family Medicine and Community Health
Family Medicine and Community Health, Prevention Research
School of Medicine
Member of the Duke Cancer Institute
Duke Cancer Institute
School of Medicine
Education:
M.S.P.H. 1989
University of North Carolina - Chapel Hill
Ph.D. 1993
University of North Carolina - Chapel Hill
Grants:
The Epidemiology of Ovarian Cancer in African American Women
Administered By
Duke Cancer Institute
Awarded By
University of Virginia - Charlottesville
Role
Principal Investigator
Start Date
End Date
Epidemiology of Ovarian Cancer in African-American Women
Administered By
Duke Cancer Institute
Awarded By
National Institutes of Health
Role
Co Investigator
Start Date
End Date
The Molecular Epidemiology Of Ovarian Cancer
Administered By
Duke Cancer Institute
Awarded By
National Institutes of Health
Role
Co Investigator
Start Date
End Date
Carolina and Georgia Genetics Network Center
Administered By
Duke Cancer Institute
Awarded By
National Institutes of Health
Role
Co Investigator
Start Date
End Date
Carolina and Georgia Genetics Network Center
Administered By
Duke Cancer Institute
Awarded By
National Institutes of Health
Role
Investigator
Start Date
End Date
Publications:
Survival of epithelial ovarian cancer in Black women: a society to cell approach in the African American cancer epidemiology study (AACES).
PURPOSE: The causes for the survival disparity among Black women with epithelial ovarian cancer (EOC) are likely multi-factorial. Here we describe the African American Cancer Epidemiology Study (AACES), the largest cohort of Black women with EOC. METHODS: AACES phase 2 (enrolled 2020 onward) is a multi-site, population-based study focused on overall survival (OS) of EOC. Rapid case ascertainment is used in ongoing patient recruitment in eight U.S. states, both northern and southern. Data collection is composed of a survey, biospecimens, and medical record abstraction. Results characterizing the survival experience of the phase 1 study population (enrolled 2010-2015) are presented. RESULTS: Thus far, ~ 650 patients with EOC have been enrolled in the AACES. The five-year OS of AACES participants approximates those of Black women in the Surveillance Epidemiology and End Results (SEER) registry who survive at least 10-month past diagnosis and is worse compared to white women in SEER, 49 vs. 60%, respectively. A high proportion of women in AACES have low levels of household income (45% < $25,000 annually), education (51% ≤ high school education), and insurance coverage (32% uninsured or Medicaid). Those followed annually differ from those without follow-up with higher levels of localized disease (28 vs 24%) and higher levels of optimal debulking status (73 vs 67%). CONCLUSION: AACES is well positioned to evaluate the contribution of social determinants of health to the poor survival of Black women with EOC and advance understanding of the multi-factorial causes of the ovarian cancer survival disparity in Black women.
Authors
Schildkraut, JM; Johnson, C; Dempsey, LF; Qin, B; Terry, P; Akonde, M; Peters, ES; Mandle, H; Cote, ML; Peres, L; Moorman, P; Schwartz, AG; Epstein, M; Marks, J; Bondy, M; Lawson, AB; Alberg, AJ; Bandera, EV
MLA Citation
Schildkraut, Joellen M., et al. “Survival of epithelial ovarian cancer in Black women: a society to cell approach in the African American cancer epidemiology study (AACES).” Cancer Causes Control, vol. 34, no. 3, Mar. 2023, pp. 251–65. Pubmed, doi:10.1007/s10552-022-01660-0.
URI
https://scholars.duke.edu/individual/pub1559960
PMID
36520244
Source
pubmed
Published In
Cancer Causes Control
Volume
34
Published Date
Start Page
251
End Page
265
DOI
10.1007/s10552-022-01660-0
Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.
BACKGROUND: Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race. METHODS: We evaluated body mass index (BMI) and invasive epithelial ovarian cancer (EOC) risk in a pooled study of case-control and nested case-control studies including AA and White women. We evaluated both young adult and recent BMI (within the last 5 years). Associations were estimated using multi-level and multinomial logistic regression models. RESULTS: The sample included 1078 AA cases, 2582 AA controls, 3240 White cases and 9851 White controls. We observed a higher risk for the non-high-grade serous (NHGS) histotypes for AA women with obesity (ORBMI 30+= 1.62, 95% CI: 1.16, 2.26) and White women with obesity (ORBMI 30+= 1.20, 95% CI: 1.02, 2.42) compared to non-obese. Obesity was associated with higher NHGS risk in White women who never used HT (ORBMI 30+= 1.40, 95% CI: 1.08, 1.82). Higher NHGS ovarian cancer risk was observed for AA women who ever used HT (ORBMI 30+= 2.66, 95% CI: 1.15, 6.13), while in White women, there was an inverse association between recent BMI and risk of EOC and HGS in ever-HT users (EOC ORBMI 30+= 0.81, 95% CI: 0.69, 0.95, HGS ORBMI 30+= 0.73, 95% CI: 0.61, 0.88). CONCLUSION: Obesity contributes to NHGS EOC risk in AA and White women, but risk across racial groups studied differs by HT use and histotype.
Authors
Ochs-Balcom, HM; Johnson, C; Guertin, KA; Qin, B; Beeghly-Fadiel, A; Camacho, F; Bethea, TN; Dempsey, LF; Rosenow, W; Joslin, CE; Myers, E; Moorman, PG; Harris, HR; Peres, LC; Wendy Setiawan, V; Wu, AH; Rosenberg, L; Schildkraut, JM; Bandera, EV
MLA Citation
Ochs-Balcom, Heather M., et al. “Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.” Br J Cancer, vol. 127, no. 11, Nov. 2022, pp. 1983–90. Pubmed, doi:10.1038/s41416-022-01981-6.
URI
https://scholars.duke.edu/individual/pub1550908
PMID
36138071
Source
pubmed
Published In
Br J Cancer
Volume
127
Published Date
Start Page
1983
End Page
1990
DOI
10.1038/s41416-022-01981-6
Race Differences in the Associations between Menstrual Cycle Characteristics and Epithelial Ovarian Cancer.
BACKGROUND: Menstrual cycle characteristics-including age at menarche and cycle length- have been associated with ovarian cancer risk in White women. However, the associations between menstrual cycle characteristics and ovarian cancer risk among Black women have been sparsely studied. METHODS: Using the Ovarian Cancer in Women of African Ancestry (OCWAA) Consortium that includes 1,024 Black and 2,910 White women diagnosed with epithelial ovarian cancer (EOC) and 2,325 Black and 7,549 White matched controls, we investigated associations between menstrual cycle characteristics (age at menarche, age at menstrual regularity, cycle length, and ever missing three periods) and EOC risk by race and menopausal status. Multivariable logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Black women were more likely to be <11 years at menarche than White women (controls: 9.9% vs. 6.0%). Compared with ≥15 years at menarche, <11 years was associated with increased EOC risk for White (OR = 1.25; 95% CI, 0.99-1.57) but not Black women (OR = 1.10; 95% CI, 0.80-1.55). Among White women only, the association was greater for premenopausal (OR = 2.20; 95% CI, 1.31-3.68) than postmenopausal women (OR = 1.06; 95% CI, 0.82-1.38). Irregular cycle length was inversely associated with risk for White (OR = 0.78; 95% CI, 0.62-0.99) but not Black women (OR = 1.06; 95% CI, 0.68-1.66). CONCLUSIONS: Earlier age at menarche and cycle irregularity are associated with increased EOC risk for White but not Black women. IMPACT: Associations between menstrual cycle characteristics and EOC risk were not uniform by race.
Authors
Nash, R; Johnson, CE; Harris, HR; Peres, LC; Joslin, CE; Bethea, TN; Bandera, EV; Ochs-Balcom, HM; Myers, ER; Guertin, KA; Camacho, F; Beeghly-Fadiel, A; Moorman, PG; Setiawan, VW; Rosenberg, L; Schildkraut, JM; Wu, AH
MLA Citation
Nash, Rebecca, et al. “Race Differences in the Associations between Menstrual Cycle Characteristics and Epithelial Ovarian Cancer.” Cancer Epidemiol Biomarkers Prev, vol. 31, no. 8, Aug. 2022, pp. 1610–20. Pubmed, doi:10.1158/1055-9965.EPI-22-0115.
URI
https://scholars.duke.edu/individual/pub1524242
PMID
35654411
Source
pubmed
Published In
Cancer Epidemiol Biomarkers Prev
Volume
31
Published Date
Start Page
1610
End Page
1620
DOI
10.1158/1055-9965.EPI-22-0115
Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.
BACKGROUND: Tumor-infiltrating lymphocytes (TIL) confer a survival benefit among patients with ovarian cancer; however, little work has been conducted in racially diverse cohorts. METHODS: The current study investigated racial differences in the tumor immune landscape and survival of age- and stage-matched non-Hispanic Black and non-Hispanic White women with high-grade serous ovarian carcinoma (HGSOC) enrolled in two population-based studies (n = 121 in each racial group). We measured TILs (CD3+), cytotoxic T cells (CD3+CD8+), regulatory T cells (CD3+FoxP3+), myeloid cells (CD11b+), and neutrophils (CD11b+CD15+) via multiplex immunofluorescence. Multivariable Cox proportional hazard regression was used to estimate the association between immune cell abundance and survival overall and by race. RESULTS: Overall, higher levels of TILs, cytotoxic T cells, myeloid cells, and neutrophils were associated with better survival in the intratumoral and peritumoral region, irrespective of tissue compartment (tumor, stroma). Improved survival was noted for T-regulatory cells in the peritumoral region and in the stroma of the intratumoral region, but no association for intratumoral T-regulatory cells. Despite similar abundance of immune cells across racial groups, associations with survival among non-Hispanic White women were consistent with the overall findings, but among non-Hispanic Black women, most associations were attenuated and not statistically significant. CONCLUSIONS: Our results add to the existing evidence that a robust immune infiltrate confers a survival advantage among women with HGSOC; however, non-Hispanic Black women may not experience the same survival benefit as non-Hispanic White women with HGSOC. IMPACT: This study contributes to our understanding of the immunoepidemiology of HGSOC in diverse populations.
Authors
Peres, LC; Colin-Leitzinger, C; Sinha, S; Marks, JR; Conejo-Garcia, JR; Alberg, AJ; Bandera, EV; Berchuck, A; Bondy, ML; Christensen, BC; Cote, ML; Doherty, JA; Moorman, PG; Peters, ES; Moran Segura, C; Nguyen, JV; Schwartz, AG; Terry, PD; Wilson, CM; Fridley, BL; Schildkraut, JM
MLA Citation
Peres, Lauren C., et al. “Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.” Cancer Epidemiol Biomarkers Prev, vol. 31, no. 5, May 2022, pp. 1006–16. Pubmed, doi:10.1158/1055-9965.EPI-21-1334.
URI
https://scholars.duke.edu/individual/pub1512202
PMID
35244678
Source
pubmed
Published In
Cancer Epidemiol Biomarkers Prev
Volume
31
Published Date
Start Page
1006
End Page
1016
DOI
10.1158/1055-9965.EPI-21-1334
Psychosocial factors associated with genetic testing status among African American women with ovarian cancer: Results from the African American Cancer Epidemiology Study.
BACKGROUND: Racial disparities in the uptake of cancer genetic services are well documented among African American (AA) women. Understanding the multiple social and psychological factors that can influence the uptake of genetic testing among AA women is needed. METHODS: Data came from 270 AA women diagnosed with ovarian cancer and participating in a population-based, case-control study of ovarian cancer who were asked about genetic testing. Logistic regression analyses tested the associations of predisposing, enabling, and need factors with reported genetic testing uptake. RESULTS: One-third of the sample (35%) reported having had genetic testing. In the multivariable model, AA women with higher incomes had more than double the odds of being tested than those with the lowest income (odds ratio [OR] for $25,000-$74,999, 2.04; 95% confidence interval [CI], 1.06-3.99; OR for ≥$75,000, 2.32; 95% CI, 0.92-5.94). AA women who reported employment discrimination were significantly less likely to report genetic testing than those who did not report job discrimination (OR, 0.39; 95% CI, 0.14-0.95). Marital status, Medicaid versus other insurance, prayer frequency, and perceived social support were significantly associated with genetic testing uptake in bivariate analyses but were not significant contributors in multivariable analyses. CONCLUSIONS: Consistent with other studies of AA women, a minority of African American Cancer Epidemiology Study participants had undergone genetic testing. Having a lower income and experiencing job discrimination decreased the likelihood of testing. These results provide foundational evidence supporting the need for interventions to improve the uptake of genetic testing among AA women by reducing cost barriers and providing credible assurances that genetic results will be kept private and not affect social factors such as employability.
Authors
McBride, CM; Pathak, S; Johnson, CE; Alberg, AJ; Bandera, EV; Barnholtz-Sloan, JS; Bondy, ML; Cote, ML; Moorman, PG; Peres, LC; Peters, ES; Schwartz, AG; Terry, PD; Schildkraut, JM
MLA Citation
McBride, Colleen M., et al. “Psychosocial factors associated with genetic testing status among African American women with ovarian cancer: Results from the African American Cancer Epidemiology Study.” Cancer, vol. 128, no. 6, Mar. 2022, pp. 1252–59. Pubmed, doi:10.1002/cncr.34053.
URI
https://scholars.duke.edu/individual/pub1503916
PMID
34882782
Source
pubmed
Published In
Cancer
Volume
128
Published Date
Start Page
1252
End Page
1259
DOI
10.1002/cncr.34053
Research Areas:
3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Acetaminophen
Adaptor Proteins, Signal Transducing
Adenocarcinoma
Adenocarcinoma, Clear Cell
Adenocarcinoma, Mucinous
Adult
African Americans
African Continental Ancestry Group
Age Distribution
Age Factors
Aged
Aged, 80 and over
Aging
Alcohol Drinking
Alleles
Amino Acid Substitution
Analysis of Variance
Anthropometry
Anti-Inflammatory Agents, Non-Steroidal
Apoptosis Regulatory Proteins
BRCA1 Protein
BRCA2 Protein
Base Sequence
Bayes Theorem
Biopsy, Needle
Body Constitution
Body Mass Index
Body Size
Bone Diseases, Metabolic
Brain Neoplasms
Breast
Breast Feeding
Breast Neoplasms
Calcium, Dietary
Carbon-Nitrogen Ligases
Carcinoma
Cardiovascular Diseases
Case-Control Studies
Caspase 8
Chemoprevention
Chemotherapy
Chi-Square Distribution
Child
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 9
Cohort Studies
Colonic Neoplasms
Colonoscopy
Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
Computer Communication Networks
Confidence Intervals
Confounding Factors (Epidemiology)
Contraception
Contraceptives, Oral
Contraceptives, Oral, Hormonal
Cooperative Behavior
Cross-Sectional Studies
Curriculum
Cyclin E
Cyclin-Dependent Kinase Inhibitor p16
Cystadenocarcinoma, Serous
Cytochrome P-450 CYP3A
DNA
DNA (Cytosine-5-)-Methyltransferase
DNA (Cytosine-5-)-Methyltransferases
DNA Damage
DNA Ligases
DNA Mutational Analysis
DNA Repair
DNA-Binding Proteins
Dairy Products
Data Collection
Demography
Diabetes
Diabetes Mellitus
Diet
Dietary Fats
Dietary Supplements
Dihydrouracil Dehydrogenase (NADP)
Drug Administration Schedule
Eczema
Educational Status
Effect Modifier, Epidemiologic
Endometrial Neoplasms
Endometriosis
Environment
Environmental Exposure
Epidemiologic Research Design
Epidemiologic Studies
Epithelial Cells
Estrogen Receptor Modulators
Estrogen Receptor alpha
Estrogen Replacement Therapy
Estrogens
Europe
European Continental Ancestry Group
Exercise
Exons
Faculty, Medical
False Positive Reactions
Family
Female
Female Urogenital Diseases
Focus Groups
Folic Acid
Follicle Stimulating Hormone
Follow-Up Studies
Food Contamination
Gene Expression Profiling
Gene Frequency
Gene-Environment Interaction
Genes, BRCA1
Genes, p53
Genetic Heterogeneity
Genetic Predisposition to Disease
Genetic Variation
Genome, Human
Genome-Wide Association Study
Genotype
Georgia
Glioma
Glycoproteins
Guidelines as Topic
Haplotypes
Health Behavior
Health Resources
Health Services Accessibility
Health Status
Heart Diseases
Heterozygote
Homozygote
Hormone Replacement Therapy
Hormones
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperplasia
Hypersensitivity
Hypertension
Hysterectomy
Immunohistochemistry
Incidence
Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Interleukin-18
International Cooperation
Interviews as Topic
Isoenzymes
Kaplan-Meier Estimate
Keratin-5
Keratin-6
Keratins
Leiomyoma
Life Style
Linear Models
Linkage Disequilibrium
Logistic Models
Loss of Heterozygosity
Lymph Node Excision
Lymph Nodes
Lymphatic Metastasis
Lymphedema
Magnetic Resonance Imaging
Male
Mammography
Maternal Age
Medical History Taking
Medical Records
Menarche
Menopause
Menstrual Cycle
Menstruation Disturbances
Methylenetetrahydrofolate Dehydrogenase (NADP)
Middle Aged
Minority Groups
Models, Statistical
Molecular Epidemiology
Molecular Sequence Data
Multivariate Analysis
Mutation
National Health Programs
Needs Assessment
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Proteins
Neoplasm Recurrence, Local
Neoplasm Staging
Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms, Radiation-Induced
Nerve Tissue Proteins
Netherlands
Neuropeptides
New Jersey
North Carolina
Nuclear Proteins
Obesity
Odds Ratio
Oligonucleotide Array Sequence Analysis
Ovarian Neoplasms
Ovary
Ovulation
Oxidative Stress
Pain
Parity
Patient Acceptance of Health Care
Patient Education as Topic
Patient Participation
Patient Selection
Pedigree
Peptides
Peritoneal Neoplasms
Pesticides
Phenotype
Physical Fitness
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Polymorphism, Single-Stranded Conformational
Population Surveillance
Postmenopause
Postoperative Complications
Pregnancy
Premenopause
Prevalence
Primary Ovarian Insufficiency
Probability
Progestins
Prognosis
Promoter Regions, Genetic
Proportional Hazards Models
Prospective Studies
Prostate-Specific Antigen
Prostatic Neoplasms
Protein-Serine-Threonine Kinases
Quality of Life
Questionnaires
Race
Radiation, Ionizing
Radiotherapy
Randomized Controlled Trials as Topic
Receptor, Epidermal Growth Factor
Receptor, erbB-2
Receptors, Androgen
Receptors, Estrogen
Receptors, Progesterone
Recreation
Registries
Regression Analysis
Reproducibility of Results
Reproductive History
Research
Residence Characteristics
Retinoblastoma Protein
Retrospective Studies
Risk
Risk Assessment
Risk Factors
Risk Management
Risk Reduction Behavior
Severity of Illness Index
Social Class
Societies, Medical
Socioeconomic Factors
Statistics as Topic
Surveys and Questionnaires
Survival Analysis
Survival Rate
Survivors
Telomerase
Thymidylate Synthase
Time Factors
Transforming Growth Factor beta1
Treatment Outcome
Trinucleotide Repeats
Tumor Cells, Cultured
Tumor Markers, Biological
Tumor Suppressor Protein p53
United States
Uterine Cervical Neoplasms
Uterine Neoplasms
Veterans
Vitamin D
Weight Gain
Women's Health
Young Adult
Professor Emeritus in Family Medicine and Community Health
Contact:
2424 Erwin Road, Suite 602, Durham, NC 27705
Box 2715 Med Ctr, Durham, NC 27710