Takuya Osada

Positions:

Associate Professor of Surgery

Surgery, Surgical Sciences
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

M.D. 1986

University of Tokyo (Japan)

Ph.D. 1997

University of Tokyo (Japan)

Grants:

Developing a HER3 Vaccine to Prevent Resistance to Endocrine Therapy

Administered By
Surgery, Surgical Sciences
Awarded By
Department of Defense
Role
Co Investigator
Start Date
End Date

Targeting the WNT/beta-catenin Pathway in Triple Negative Breast Cancer

Administered By
Medicine, Medical Oncology
Awarded By
Department of Defense
Role
Investigator
Start Date
End Date

Targeting hCG-beta for Breast Cancer Immunotherapy

Administered By
Duke Cancer Institute
Awarded By
National Institutes of Health
Role
Research Analyst
Start Date
End Date

Dendritic Cell Mobilization and Active Immunotherapy

Administered By
Surgery, Surgical Sciences
Awarded By
National Institutes of Health
Role
Investigator
Start Date
End Date

Redirecting Specificity of Viral Specific T Cells

Administered By
Surgery, Surgical Sciences
Awarded By
National Institutes of Health
Role
Research Scientist
Start Date
End Date

Publications:

Abstract 4071: A novel combination therapy of high intensity focused ultrasound and PDL1 blockades against advanced breast cancer

Authors
Abe, S; Osada, T; Kaneko, K; Zhong, P; Lyerly, HK
MLA Citation
Abe, Shinya, et al. “Abstract 4071: A novel combination therapy of high intensity focused ultrasound and PDL1 blockades against advanced breast cancer.” Immunology, American Association for Cancer Research, 2019. Crossref, doi:10.1158/1538-7445.am2019-4071.
URI
https://scholars.duke.edu/individual/pub1416574
Source
crossref
Published In
Immunology
Published Date
DOI
10.1158/1538-7445.am2019-4071

Abstract 3731: A novel heat shock protein 90-targeted photosensitizer (HS-201) enables enhanced tumor-specific photodynamic therapy of inflammatory breast cancers

Authors
Kaneko, K; Osada, T; Hughes, PF; Haystead, TA; Morse, MA; Lyerly, HK
MLA Citation
Kaneko, Kensuke, et al. “Abstract 3731: A novel heat shock protein 90-targeted photosensitizer (HS-201) enables enhanced tumor-specific photodynamic therapy of inflammatory breast cancers.” Tumor Biology, American Association for Cancer Research, 2019. Crossref, doi:10.1158/1538-7445.am2019-3731.
URI
https://scholars.duke.edu/individual/pub1417346
Source
crossref
Published In
Tumor Biology
Published Date
DOI
10.1158/1538-7445.am2019-3731

Abstract P2-09-16: CD8 T cells induced by novel alphaviral vector predict improved progression free survival in advanced HER2+ breast cancer patients

Authors
Crosby, EJ; Gwin, WR; Chang, S; Maecker, HT; Lubkov, V; Snyder, JC; Broadwater, G; Hyslop, T; Osada, T; Hobeika, AC; Hartman, ZC; Morse, MA; Lyerly, HK
MLA Citation
Crosby, E. J., et al. “Abstract P2-09-16: CD8 T cells induced by novel alphaviral vector predict improved progression free survival in advanced HER2+ breast cancer patients.” Poster Session Abstracts, American Association for Cancer Research, 2019. Crossref, doi:10.1158/1538-7445.sabcs18-p2-09-16.
URI
https://scholars.duke.edu/individual/pub1404161
Source
crossref
Published In
Poster Session Abstracts
Published Date
DOI
10.1158/1538-7445.sabcs18-p2-09-16

Determining effect of food intake on comprehensive abdominal-pelvic visceral blood flow by Doppler ultrasound

Aim: Comprehensive arterial blood flow (BF) in the abdominal-pelvic viscera (BFVis) can be calculated by subtracting right and left femoral arterial BF (BFRFA and BFLFA, respectively) from upper abdominal aorta BF (BFAo) above the coeliac trunk. The aim of the present study was to evaluate the time course in BFVis and its relation to hemodynamic parameters following food intake using pulsed Doppler ultrasound. Method: Pre- and post-prandial BFAo, BFRFA, and BFLFA were determined in 9 healthy subjects at 5, 15, 30, 45, 65, and 85 min after intake of 800 kcal solid food. The BFVis was calculated by subtracting both BFFAs from BFAo. Blood pressure and heart rate were also measured at each point. Results: An increase was observed in postprandial BFAo at between 15 and 45 min. Postprandial BFRFA increased at 15 min. An increase was observed in postprandial BFVis at 5 min, with the peak value (increase of 887 ml/min compared to value at before food intake) occurring at 15 min; further increase was maintained until 45 min, after which it recovered to pre-food intake values at 85 min. A linear correlation was observed between BFAo and BFVis (r=0.99, P<.0001), as well as between BFAo and both femoral arterial BFs (r=0.91, P<.01). There was no postprandial change in BP or HR. Conclusion: The postprandial BFVis was closely related to BFAo. This suggests that a rise in BFVis indicates an increase in stroke volume, and that BF to the coeliac trunk and superior/inferior mesenteric artery increases due to vasodilation in the splanchnic vascular bed. These results indicate that the type of measurements used in this study may serve as a useful indicator in investigating the time course in BFVis due to food intake.
Authors
Nagata, H; Osada, T; Murase, N; Kime, R; Katsumura, T
MLA Citation
Nagata, H., et al. “Determining effect of food intake on comprehensive abdominal-pelvic visceral blood flow by Doppler ultrasound.” Journal of Tokyo Medical University, vol. 73, no. 1, Jan. 2015, pp. 35–44.
URI
https://scholars.duke.edu/individual/pub1351602
Source
scopus
Published In
Journal of Tokyo Medical University
Volume
73
Published Date
Start Page
35
End Page
44

Modulation of Immune System Inhibitory Checkpoints in Colorectal Cancer

Authors
Patel, SP; Osada, T; Osada, K; Hurwitz, H; Lyerly, HK; Morse, MA
MLA Citation
Patel, S. P., et al. “Modulation of Immune System Inhibitory Checkpoints in Colorectal Cancer.” Current Colorectal Cancer Reports, 2013, pp. 1–7.
URI
https://scholars.duke.edu/individual/pub962150
Source
scopus
Published In
Current Colorectal Cancer Reports
Published Date
Start Page
1
End Page
7