Daniel Rocke

Positions:

Assistant Professor of Head and Neck Surgery & Communication Sciences

Head and Neck Surgery & Communication Sciences
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

M.D. 2009

University of Michigan, Ann Arbor

General Surgery Internship, Department Of Surgery

Duke University

Otolaryngology-Head & Neck Surgery Resident, Department Of Surgery

Duke University

Head & Neck Surgical Oncology Fellow, Department Of Surgery

University of Toronto (Canada)

Grants:

Adapting a machine learning algorithm to predict thyroid cytopathologyin LMIC

Administered By
Head and Neck Surgery & Communication Sciences
Awarded By
National Institutes of Health
Role
Co Investigator
Start Date
End Date

Publications:

Surgeon Volume and Complications in Lateral Neck Dissection for Squamous Cell Carcinoma: A Multidatabase Analysis.

OBJECTIVE: To determine whether annual surgeon volume of lateral neck dissections for squamous cell carcinoma is associated with complication rates. STUDY DESIGN: Retrospective review. SETTING: Two US databases spanning 2000 to 2014. METHODS: Neck dissections for squamous cell carcinoma from the National Inpatient Sample and State Inpatient Databases were analyzed. The primary outcome was any in-hospital complication common to neck dissection. The principal independent variable was surgeon volume. A multivariable logistic generalized estimating equation with a piecewise linear spline for surgeon volume was fit to assess its association with complication. RESULTS: The National Inpatient Sample had 3517 discharges fitting criteria, a median surgeon volume of 12, and an 11.1% complication rate. A 1-unit increase in surgeon volume was associated with a 7% increase in the odds of complication when volume ranged between 4 and 19 (adjusted odds ratio [AOR], 1.07; 95% CI, 1.04-1.11) and with a 3% decrease in the odds of complication when volume ranged between 19 and 51 (AOR, 0.97; 95% CI, 0.96-0.99). The State Inpatient Databases had 2876 discharges fitting criteria, a median surgeon volume of 30, and a 13.5% complication rate. Surgeon volume was not associated with complication when <27 (AOR, 1.01; 95% CI, 0.99-1.02), but a 5-unit increase in volume was associated with a 7% decrease in the odds of complication with volume ≥27 (AOR, 0.93; 95% CI, 0.88-0.98). CONCLUSIONS: Surgeon volume was associated with complications for most volume ranges and with lower odds of complication for high-volume surgeons.
Authors
Campbell, JC; Lee, H-J; Cannon, T; Kahmke, RR; Lee, WT; Puscas, L; Rocke, DJ
MLA Citation
Campbell, James C., et al. “Surgeon Volume and Complications in Lateral Neck Dissection for Squamous Cell Carcinoma: A Multidatabase Analysis.Otolaryngol Head Neck Surg, Mar. 2021, p. 1945998211000438. Pubmed, doi:10.1177/01945998211000438.
URI
https://scholars.duke.edu/individual/pub1475823
PMID
33689518
Source
pubmed
Published In
Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery
Published Date
Start Page
1945998211000438
DOI
10.1177/01945998211000438

Postoperative radiotherapy is associated with improved overall survival for alveolar ridge squamous cell carcinoma with adverse pathologic features.

BACKGROUND: Alveolar ridge squamous cell carcinoma (ARSCC) is poorly represented in randomized trials. METHODS: Adults in the National Cancer Database diagnosed with ARSCC between 2010 and 2014 who should be considered for postoperative radiotherapy (PORT) based on National Comprehensive Cancer Network (NCCN)-defined risk factors were identified. RESULTS: Eight hundred forty-five (58%) of 1457 patients meeting the inclusion criteria received PORT. PORT was associated with improved overall survival (OS) on unadjusted (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.70-0.98, P = .02) and multivariable (HR 0.78, 95% CI 0.64-0.94, P = .002) analyses. PORT was associated with significantly improved 5-year OS for patients with 1 (68% vs 58%, P < .001), 2 (52% vs 31%, P < .001), and ≥3 (38% vs 24%, P < .001) NCCN-defined risk factors. Prognostic variables significantly associated with worse OS on multivariable analysis included advanced age, primary tumor size ≥3 cm, high grade, positive margin(s), stage N2-3, level IV/V nodal metastasis, and extranodal extension. CONCLUSION: PORT for resected ARSCC with adverse pathologic features is associated with significantly improved OS.
Authors
Jacobs, CD; Williamson, H; Barak, I; Rocke, DJ; Kahmke, RR; Suneja, G; Mowery, YM
MLA Citation
Jacobs, Corbin D., et al. “Postoperative radiotherapy is associated with improved overall survival for alveolar ridge squamous cell carcinoma with adverse pathologic features.Head Neck, vol. 43, no. 1, Jan. 2021, pp. 203–11. Pubmed, doi:10.1002/hed.26475.
URI
https://scholars.duke.edu/individual/pub1460955
PMID
32969107
Source
pubmed
Published In
Head Neck
Volume
43
Published Date
Start Page
203
End Page
211
DOI
10.1002/hed.26475

Plasmonic assay for amplification-free cancer biomarkers detection in clinical tissue samples.

Developing countries have seen a rise in cancer incidence and are projected to harbor three-quarters of all cancer-related mortality by 2030. While disproportionally affected by the burden of cancer, these regions are ill-equipped to handle the diagnostic caseload. The low number of trained pathologists per capita results in delayed diagnosis and treatment, ultimately contributing to increased mortality rates. To address this issue, we developed a point-of-care (POC) plasmonic assay for direct detection of cancer as an alternative to pathological review. Whereas our assay has general applicability in many cancer diagnoses that involve tissue biopsies, we use head and neck cancer (HNC) as a model system because these tumors are increasingly prevalent in lower-income and underserved regions, due to risk factors such as smoking, drinking, and viral infection. Our method uses surface-enhanced Raman scattering (SERS) to detect unique RNA biomarkers from human biopsy samples without the need for complex target amplification machinery (e.g., PCR), making it time and resource-efficient. Unlike previous studies that required target amplification, this work represents a significant advance for HNC diagnosis directly in clinical samples, using only our SERS-based assay for RNA biomarkers. In this study, we tested our assay on 20 clinical samples, demonstrating the accuracy of the method in the diagnosis of head and neck squamous cell carcinoma. We reported sensitivity of 100% and specificity of 97%. Furthermore, we used a handheld Raman device to read the results in order to illustrate the applicability of our method for POC diagnosis of cancer in low-resource settings.
Authors
Dukes, PV; Strobbia, P; Ngo, HT; Odion, RA; Rocke, D; Lee, WT; Vo-Dinh, T
MLA Citation
Dukes, Priya V., et al. “Plasmonic assay for amplification-free cancer biomarkers detection in clinical tissue samples.Anal Chim Acta, vol. 1139, Dec. 2020, pp. 111–18. Pubmed, doi:10.1016/j.aca.2020.09.003.
URI
https://scholars.duke.edu/individual/pub1459134
PMID
33190693
Source
pubmed
Published In
Anal Chim Acta
Volume
1139
Published Date
Start Page
111
End Page
118
DOI
10.1016/j.aca.2020.09.003

A Retrospective Study of Lymph Node Yield in Lateral Neck Dissection for Papillary Thyroid Carcinoma.

OBJECTIVE: Lateral neck dissection (LND) is important in managing papillary thyroid carcinomas (PTCs). This study aimed to evaluate the relationship between lymph node yield (LNY) for LND and patient outcomes, specifically postoperative serum thyroglobulin levels (sTG) and radioiodine uptake on thyroid scan, and to estimate a threshold LNY to signify adequate LND. METHODS: Patients diagnosed with PTC who underwent LND from 2006 to 2015 at a single institution were included. Linear regression with restricted cubic splines was used to characterize the association of LNY with outcomes. Outcomes were log-transformed to achieve a more symmetric distribution prior to regression. For nonlinear associations, a Monte Carlo Markov Chain procedure was used to estimate a threshold LNY associated with postoperative outcome. This threshold was then used to define high LNY versus low LNY in the subsequent analyses. RESULTS: In total, 107 adult patients were included. There was a significant relationship between LNY and postoperative sTG level (P = .004), but not radioiodine uptake (P = .64). An LNY of 42.96 was identified, which was associated with the maximum change in sTG level. No association was found between LNY groups (LNY ≥ 43 vs < 43) and radioiodine uptake, risk of complication, or longer operative times (all P > .05). High LNY was associated with a decrease in log(sTG) (estimate = -1.855, P = .03), indicating that adequacy of LND is associated with an 84.4% decrease in sTG. CONCLUSION: These results suggest an association between LNY and postoperative sTG level, with an estimated threshold of 43 nodes. This has implications for adequate therapeutic LND; additional work is needed to validate thresholds for clinical practice.
Authors
Issa, K; Stevens, MN; Sun, Y; Thomas, S; Collins, A; Cohen, J; Esclamado, RM; Rocke, DJ
MLA Citation
Issa, Khalil, et al. “A Retrospective Study of Lymph Node Yield in Lateral Neck Dissection for Papillary Thyroid Carcinoma.Ear Nose Throat J, Oct. 2020, p. 145561320967339. Pubmed, doi:10.1177/0145561320967339.
URI
https://scholars.duke.edu/individual/pub1463032
PMID
33090902
Source
pubmed
Published In
Ear Nose Throat J
Published Date
Start Page
145561320967339
DOI
10.1177/0145561320967339

Association of Lymph Node Ratio With Overall Survival in Patients With Metastatic Papillary Thyroid Cancer.

Authors
Smith, BD; Oyekunle, TO; Thomas, SM; Puscas, L; Rocke, DJ
MLA Citation
Smith, Blaine D., et al. “Association of Lymph Node Ratio With Overall Survival in Patients With Metastatic Papillary Thyroid Cancer.Jama Otolaryngol Head Neck Surg, vol. 146, no. 10, Oct. 2020, pp. 962–64. Pubmed, doi:10.1001/jamaoto.2020.2053.
URI
https://scholars.duke.edu/individual/pub1454209
PMID
32761147
Source
pubmed
Published In
Jama Otolaryngol Head Neck Surg
Volume
146
Published Date
Start Page
962
End Page
964
DOI
10.1001/jamaoto.2020.2053