Lars Wagner
Overview:
I am a pediatric oncologist with a clinical and research focus on the care of adolescents and young adults with sarcoma. I have led multiple institutional and national clinical trials exploring new therapies for patients with recurrent sarcoma, and am interested in new drug development and identification of predictive biomarkers.
Positions:
Professor of Pediatrics
Pediatrics, Hematology-Oncology
School of Medicine
Chief, Division of Hematology/Oncology
Pediatrics, Hematology-Oncology
School of Medicine
Member of the Duke Cancer Institute of the
Duke Cancer Institute
School of Medicine
Education:
M.D. 1991
University of Kentucky, College of Medicine
Residency, Pediatrics
University of Tennessee Health Science Center
Hematology/Oncology Fellowship, St Jude Children's Hospital
University of Tennessee Health Science Center
Grants:
Per Case Reimbursement : NIH National Clinical Trials Network (NCTN)
Administered By
Pediatrics, Hematology-Oncology
Awarded By
Children's Hospital of Philadelphia
Role
Principal Investigator
Start Date
End Date
A Multi-Center Phase III, Randomized, Open-Label Trial of Vigil (bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) in combination with Irinotecan and Temozolomide as a Second-Line Regimen for Ewing's Sarcoma (CL-PTL-130)
Administered By
Pediatrics, Hematology-Oncology
Awarded By
Gradalis, Inc.
Role
Principal Investigator
Start Date
End Date
Workload Intensity NIH National Clinical Trials Network (NCTN)
Administered By
Pediatrics, Hematology-Oncology
Awarded By
Children's Hospital of Philadelphia
Role
Principal Investigator
Start Date
End Date
NCI Community Oncology Research Program (NCORP) Research Base Grant
Administered By
Pediatrics, Hematology-Oncology
Awarded By
Children's Hospital of Philadelphia
Role
Principal Investigator
Start Date
End Date
Project: One Time EOY, Integrated BIQSFP AAML1031- Echocardiogram Reports and Images
Administered By
Pediatrics, Hematology-Oncology
Awarded By
Children's Hospital of Philadelphia
Role
Principal Investigator
Start Date
End Date
Publications:
A PHASE I TRIAL OF MK-0752 IN PEDIATRIC PATIENTS WITH RECURRENT OR REFRACTORY CNS MALIGNANCIES: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY
Authors
MLA Citation
Fouladi, Maryam, et al. “A PHASE I TRIAL OF MK-0752 IN PEDIATRIC PATIENTS WITH RECURRENT OR REFRACTORY CNS MALIGNANCIES: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY.” Neuro Oncology, vol. 14, OXFORD UNIV PRESS INC, 2012, pp. 115–115.
URI
https://scholars.duke.edu/individual/pub929221
Source
wos
Published In
Neuro Oncology
Volume
14
Published Date
Start Page
115
End Page
115
Management of recurrent Ewing sarcoma: challenges and approaches.
Although many patients with newly diagnosed Ewing sarcoma can become long-term survivors, relapse remains an important clinical problem for which there is no standard approach. Several prognostic factors have been identified, and these may help guide patient counseling and therapy decisions. A variety of chemotherapy regimens have produced responses in patients with recurrent Ewing sarcoma, but no comparative studies have been completed to show superiority of any one particular approach. In addition, the optimum length of therapy for salvage regimens and use of local control measures remains unknown. The likelihood of cure remains low and the gaps in our knowledge are great, and so enrollment on clinical trials should be strongly encouraged for these patients when feasible. Because Ewing sarcoma is relatively rare, some pediatric and adult oncologists may be less familiar with the management of relapsed patients. In this review, we address common questions facing the clinician and patient, and provide an update on new strategies for therapy.
Authors
MLA Citation
Van Mater, David, and Lars Wagner. “Management of recurrent Ewing sarcoma: challenges and approaches.” Onco Targets Ther, vol. 12, 2019, pp. 2279–88. Pubmed, doi:10.2147/OTT.S170585.
URI
https://scholars.duke.edu/individual/pub1381184
PMID
30988632
Source
pubmed
Published In
Oncotargets and Therapy
Volume
12
Published Date
Start Page
2279
End Page
2288
DOI
10.2147/OTT.S170585

Professor of Pediatrics