We are doing this study to see if an experimental combination of drugs (D2C7-IT and 2141-V11) is a safe treatment for brain tumors.

Brain Tumors

Adults 18 years of age and older who:

• Are diagnosed with Grade III or IV malignant glioma that has progressed or recurred
• Do not take a high dose of a steroid medicine called Decadron or dexamethasone
• Are not taking any types of medicines that affect your immune system

For more information about this study, please contact the team at 919-684-5301.

If you choose to join this study, you will:

• Have the study drugs (D2C7-IT and 2141-V11) put into the area around your tumor
• Stay in the hospital for approximately 4 days
• Have physical exams
• Give blood samples
• Have MRI scans

You will have regular follow-up visits after you leave the hospital. You will have a return clinic visit 2 weeks, 4 weeks, and 8 weeks after your hospital stay and then every 8 weeks for at least one year.