Corinne Linardic
Associate Professor of PediatricsOverview
Pediatric Sarcomas: Sarcomas are among the most difficult-to-treat cancers in pediatric oncology, with metastatic forms having the highest mortality. We have established genetically defined human cell-based models and genetically engineered murine models for the pediatric skeletal muscle cancer known as rhabdomyosarcoma. Using these models, we can study the causative role of certain genetic changes (e.g. chromosomal translocations and oncogenic RAS) in rhabdomyosarcoma formation and treatment resistance. Specific goals of this research program include the identification of signaling pathways corrupted in rhabdomyosarcoma, with focus on the PAX3-FOXO1 mutation and its downstream effectors and oncogenic RAS, and identification of new therapeutic targets for treatment of this childhood cancer.
Positions
Associate Professor of Pediatrics in the School of Medicine
2012 School of Medicine
Associate Professor of Cell Biology in the School of Medicine
2022 School of Medicine
Associate Professor of Pharmacology and Cancer Biology in the School of Medicine
2012 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
1999 School of Medicine
Education
Ph.D. 1993
1993 Duke University
M.D. 1995
1995 Duke University
Residency, Pediatrics
1998 Children's Hospital of Philadelphia
Fellow, Pediatric Hematology-Oncology, Pediatrics
1999 Children's Hospital of Philadelphia
Fellow, Pediatric Hematology-Oncology, Pediatrics
2001 Duke University
Board Certification Hematology and Oncology
9999 American Board of Pediatrics
Publications, Grants & Awards
DCI Centers, Cancer Types & Labs
Offices & Contact
Durham, NC
27710 Box 102382, DUMC
Durham, NC
27710