We are doing this study to find out if an experimental drug called AMG 355 (the study drug) is a safe and effective option for people who have a solid tumor form of cancer that is metastatic (spread to surrounding tissues in the body). We want to know how well the study drug works on its own or in combination with an approved cancer drug called pembrolizumab.

Metastatic, Advanced Solid Tumor Cancers

Adults ages 18+ who have one of the following forms of cancer that has come back after treatment or did not respond to standard therapy:

• Non-small cell lung cancer
• Colorectal cancer
• Gastric cancer
• Melanoma

For more information, contact the study team at ryan.woelfel@duke.edu.

If you choose to join this study, you will get a random assignment (like a coin flip) to 1 of 2 groups:

• Group A: If you are in this group, you will take only the study drug while you are in the study.
• Group B: If you are in this group, you will take the study drug in combination with pembrolizumab while you are in the study.