APL-5125 (Gastrointestinal Cancers)

What is the Purpose of this Study?

We are doing this study to find out if an experimental drug called APL-5125 (the study drug) is a safe and effective for people with select types of gastrointestinal cancer. We are also trying to find the best dose of APL-5125 to use.

What is the Condition Being Studied?

Gastrointestinal Cancers

Who Can Participate in the Study?

Adults ages 18+ who have locally advanced or metastatic tumors of one of the following types:

  • Colorectal carcinoma
  • Cholangiocarcinoma
  • Appendiceal adenocarcinoma

For more information about this study, contact the study team at 919-668-1861.

Age Group
Adults

What is Involved?

If you choose to join this study, you will:

  • Take the study drug, APL-5125, by mouth every day
  • Have your tumor biopsied
  • Give blood and urine samples
  • Have regular CT or MRI scans

Study Details

Full Title
[AP10CP01] A Phase 1/2 Study to Assess the Safety and Antitumor Activity of APL-5125 in Adults with Selected Advanced Solid Tumors
Principal Investigator
Headshot of John Strickler
Professor of Medicine
Protocol Number
IRB: PRO00115529
NCT: NCT06399757
Phase
Phase I/II
ClinicalTrials.gov
Enrollment Status
OPEN TO ACCRUAL
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