We are doing this study to see if a pair of experimental drugs called botensilimab and balstilimab are safe and effective options for colorectal cancer.

Colorectal Cancer

Adults ages 18+ who:

• Are diagnosed with unresectable or metastatic colorectal cancer
• Do not have metastases to the liver, bone, or brain
• Have not received prior therapy for their current cancer

For more information, contact the study team at justinemae.flores@duke.edu.

If you choose to join this study, you will:

• Get the study drug balstilimab by IV once every 2 weeks for up to 2 years
• Get the study drug botensilimab by IV on weeks 1, 7, 13, and 19 while you are getting balstilimab
• Receive standard anti-cancer drugs if your cancer does not improve on the study regimen
• Have your tumor biopsied
• Have blood draws
• Have regular CT or MRI scans