We are doing this study to find out if an experimental drug called KO-539 (study drug) is a safe and effective treatment for AML. We want to know if it might be beneficial for people with AML that is resistant to standard treatments.

Acute Myeloid Leukemia (AML)

Adults ages 18+ who have AML that is not responding to standard therapies.

For more information about who can join this study, please contact the study team at 919-660-2077.

If you choose to join this study, you will take the study drug by mouth each day. This drug is taken once a day continuously in 28-day cycles.

Your study doctor will assess how you are doing at the end of each drug cycle. How many drug cycles you do will depend on:

• How well you tolerate the study drug
• How well your cancer responds to the drug
• Your overall health

When you stop taking the study drug, we will follow up with you each month either over the phone or in the clinic to see how you are doing. This monthly follow-up may continue for up to 6 months.