We are doing this study to find out if adding radiation therapy has any positive benefit when it is added to the usual treatment regimen for this form of cancer.

Metastatic or Unresectable Renal Cell Cancer

Adults ages 18+ who are diagnosed with renal cell cancer that is metastatic (spread beyond the kidney) or unresectable (cannot be removed by surgery).

For more information, contact the study team at nick.jeffries@duke.edu.

If you choose to join this study, you will get a random assignment (like a coin flip) to 1 of 2 groups:

• Group 1: If you are in this group, you will get the usual immune therapy used to treat this type of cancer. You will get the immune therapy as an infusion through a vein in the arm, and if you also receive a VEGF drug, you will receive this as a pill you take by mouth
• Group 2: If you are in this group, you will receive radiation therapy plus the usual immune therapy used to treat this type of cancer as described above. The radiation treatments will be given on 3 different days over the course of 1-3 weeks.