Michael D Deel
Assistant Professor of PediatricsOverview
Dr. Deel is a clinician scientist in Pediatric Hematology/Oncology. In addition to caring for pediatric patients with hematologic disorders or malignancy, his research focuses on finding novel ways to target fusion-positive pediatric sarcomas. His current work focuses on understanding the gene regulation and molecular pathways responsible for alveolar rhabdomyosarcoma, which is among the most difficult to cure pediatric cancers. Alveolar rhabdomyosarcoma is driven by chromosomal translocations t(2;13) or t(1;13) that result in oncogenic transcription factors encoding for PAX3/7-FOXO1 fusion proteins. The PAX3/7-FOXO1 oncogenes are currently not viable therapeutic targets. Using a variety of cell culture and murine models, Dr. Deel is investigating genes and pathways that regulate or coordinate PAX3/7-FOXO1-mediated tumorigenesis.
Positions
Assistant Professor of Pediatrics in the School of Medicine
2021 School of Medicine
Member of the Duke Cancer Institute in the School of Medicine
2018 School of Medicine
Education
M.D. 2010
2010 Marshall University, Joan C. Edwards School of Medicine
Internshipand Residency, PEDIATRICS/UNIVERSITY OF LOUISVILLE
2013 University of Louisville
Pediatric Hematology/Oncology Fellowship, PEDIATRICS/DUKE UNIVERSITY SCHOOL OF MEDICINE
2016 Duke University, School of Medicine
Advanced Pediatric/Oncology Research Training, PEDIATRICS/DUKE UNIVERSITY SCHOOL OF MEDICINE
2017 Duke University, School of Medicine
Publications, Grants & Awards
DCI Centers, Cancer Types & Labs
Offices & Contact
Durham, NC
27710 Duke University
Durham, NC
27710